Cells and biomaterials for intervertebral disc regeneration

Cells and biomaterials for intervertebral disc regeneration

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Bibliographic Details
Imprint:San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, c2010.
Description:1 electronic text (viii, 96 p. : ill.) : digital file.
Language:English
Series:Synthesis lectures on tissue engineering, 1944-0308 ; # 5
Synthesis digital library of engineering and computer science.
Synthesis lectures on tissue engineering, # 5.
Subject:
Intervertebral disk -- Regeneration.
Intervertebral Disk.
Regeneration.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/10510933
Hidden Bibliographic Details
Other authors / contributors:Grad, Sibylle.
ISBN:9781608454655 (electronic bk.)
9781608454648 (pbk.)
Notes:Part of: Synthesis digital library of engineering and computer science.
Title from PDF t.p. (viewed on July 13, 2010).
Series from website.
Includes bibliographical references (p. 24-39, 70-94).
Abstract freely available; full-text restricted to subscribers or individual document purchasers.
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Mode of access: World Wide Web.
System requirements: Adobe Acrobat Reader.
Summary:Disorders related to the intervertebral disc (IVD) are common causes of morbidity and of severe life quality deterioration. IVD degeneration, although in many cases asymptomatic, is often the origin of painful neck and back diseases. In Western societies IVD related pain and disability account for enormous health care costs as a result of work absenteeism and thus lost production, disability benefits, medical and insurance expenses. Although only a small percentage of patients with disc disorders finally will undergo surgery, spinal surgery has been one of the fastest growing disciplines in the musculoskeletal field in recent years. Nevertheless, current treatment options are still a matter of controversial discussion. In particular, they hardly can restore normal spine biomechanics and prevent degeneration of adjacent tissues. While degeneration affects all areas of the IVD, the most constant and noticeable changes occur in the gel-like central part, the nucleus pulposus (NP). Recent emphasis has therefore been put in biological ways to regenerate the NP; however, there are a number of obstacles to overcome, considering the exceptional biological and biomechanical environment of this tissue. Different biological approaches such as molecular, gene, and cell based therapies have been investigated and have shown promising results in both in vitro and in vivo studies. Nonetheless, considerable hurdles still exist in their application for IVD regeneration in human patients. The choice of the cells and the choice of the cell carrier suitable for implantation pose major challenges for research and development activities. This lecture recapitulates the basics of IVD structure, function, and degeneration mechanisms. The first part reviews the recent progress in the field of disc and stem cell based regenerative approaches. In the second part, most appropriate biomaterials that have been evaluated as cell or molecule carrier to cope with degenerative disc disease are outlined. The potential and limitations of cell- and biomaterial-based treatment strategies and perspectives for future clinical applications are discussed.
Standard no.:10.2200/S00250ED1V01Y201006TIS005
Table of Contents:
  • 1. Cell therapy for nucleus pulposus regeneration / Sibylle Grad and Mauro Alini ; Daisuke Sakai and Joji Mochida
  • Introduction
  • Intervertebral disc degeneration
  • Normal disc structure and function
  • Aging and degeneration
  • Cell based nucleus pulposus regeneration
  • Disc cell based approaches
  • Stem cell based approaches
  • Limitations and future perspective
  • Acknowledgements
  • References
  • Authors' biographies
  • 2. Recent advances in biomaterial based tissue engineering for intervertebral disc regeneration / Sunil Mahor, Estelle Collin, Biraja Dash, and Abhay Pandit ; David Eglin
  • Introduction
  • Intervertebral disc: structure, function and cells
  • Anatomy of the intervertebral disc
  • Extracellular matrix
  • Cells of the intervertebral disc
  • Intervertebral disc degeneration: etiology
  • Current treatments for degenerative disc disease
  • Biomaterials for engineering of intervertebral disc tissue
  • Selection of biomaterials
  • Biopolymers
  • Synthetic polymers
  • Polymeric hydrogels for in vitro nucleus pulposus regeneration studies
  • Polymeric hydrogels for in vivo nucleus pulposus regeneration
  • Future perspectives
  • Acknowledgements
  • References
  • Authors' biographies.

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