Molecular determinants of head and neck cancer /

Molecular determinants of head and neck cancer /

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Bibliographic Details
Imprint:	New York : Springer, [2014] ©2014
Description:	1 online resource (ix, 362 pages) : illustrations (chiefly color).
Language:	English
Series:	Current cancer research Current cancer research.
Subject:	Head -- Cancer -- Diagnosis. Neck -- Cancer -- Diagnosis. Head -- Cancer -- Treatment. Neck -- Cancer -- Treatment. Head -- Cancer -- Diagnosis. Head -- Cancer -- Treatment. Neck -- Cancer -- Diagnosis. Neck -- Cancer -- Treatment.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11084378

Hidden Bibliographic Details
Other authors / contributors:	Burtness, Barbara, editor. Golemis, Erica, editor.
ISBN:	9781461488156 146148815X 9781461488149 1461488141
Notes:	Print version record.
Summary:	Head and neck cancers, involving sites from the nasopharynx to the subglottic larynx, are frequently devastating cancers that afflict patients around the world. These cancers are frequently locally advanced prior to detection, and require multimodality therapy that is associated with high morbidity. As this book addresses this difficult disease, it accomplishes three main goals. First, it introduces the etiology and subclasses of squamous cell carcinomas of the head and neck (SCCHNs), and how these factors affect prognosis. Although habitual exposures to tobacco, alcohol, and other agents have historically been the main causes of SCCHN, a rising proportion of oropharynx cancers arise from transforming human papillomavirus (HPV) infection. These two broad classes of SCCHN have significant differences in disease profile and response to treatment, as we discuss. Second, it summarizes the current state of understanding of the genetic, epigenetic and protein expression changes associated with the various classes of SCCHN. In the past decade, disease pathogenesis of SCCHN has been appreciated to involve deregulation of multiple tumor pathways, including the receptor tyrosine kinases (RTKs) EGFR, ERBB2, ERBB3, c-MET, and IGF1R; transforming growth factor c (TGFc); Notch; cytoplasmic signaling proteins including PTEN, PI3K, JAK/STAT, and Wnt-responsive c-catenin; mutation control systems, including p53 and the DNA damage repair (DDR) machinery; and hypoxic response. The specific understanding of the action of these proteins in SCCHN is presented here. Finally, this book defines potential therapeutic targets for improved management of the disease in the future, discussing prospects for improved prediction of prognosis.
Other form:	Print version: Molecular Determinants of Head and Neck Cancer. Springer Verlag 2014 9781461488149
Standard no.:	10.1007/978-1-4614-8815-6

Description
Summary:	Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. In the past several years, there have been significant developments in understanding of HNC. It is now recognized that although alcohol and tobacco use has represented the likely predominant cause of SCCHN, the incidence of a second class of SCCHN related to oncogenic human papillomavirus (HPV) infection is increasing, with a four-fold increase in the past 2 decades, and now thought to represent up to 30% of cases. The first effective target for SCCHN, the EGFR-targeting antibody cetuximab, was approved as recently as in 2006; since then, a growing body of research has identified additional signaling pathways as important in disease pathogenesis, and in resistance to treatment. Proteins such as c-Met, Src, and HER2 are emerging as new therapeutic targets, with a considerable ferment in the clinical trial community. As a capstone of research progress, 2011 marked the first reports of high throughput sequencing of SCCHN tumors, with these efforts identifying unexpected players such as Notch as frequent subject of mutation, spawning new hypotheses for future research. This book will be of interest to researchers who are interested in better understanding the biology of head and neck cancers, with the goals of better designing therapies, identifying risk factors, or investigating the molecular basis of the disease.
Physical Description:	1 online resource (ix, 362 pages) : illustrations (chiefly color).
ISBN:	9781461488156 146148815X 9781461488149 1461488141