Sphingosine-1-phosphate signaling in immunology and infectious diseases /

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Bibliographic Details
Imprint:	Cham ; New York : Springer, [2014] ©2014
Description:	1 online resource (vii, 184 pages) : illustrations.
Language:	English
Series:	Current topics in microbiology and immunology, 0070-217X ; volume 378 Current topics in microbiology and immunology ; 378.
Subject:	Immunopharmacology. Sphingosine -- Immunology. Phosphates -- Immunology. Immunopharmacology.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11084533

Hidden Bibliographic Details
Other authors / contributors:	Oldstone, Michael B. A., editor. Rosen, Hugh (Professor of chemical physiology), editor.
ISBN:	9783319058795 3319058797 3319058789 (print) 9783319058788 (print)
Notes:	Includes bibliographical references and index. Description based on PDF title page (viewed April 22, 2014).
Summary:	This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.
Other form:	Print version: Sphingosine-1-phosphate signaling in immunology and infectious diseases. Cham, Switzerland : Springer, [2014] 3319058789
Standard no.:	10.1007/978-3-319-05879-5

Table of Contents:

The organization of the sphingosine-1-phosphate signaling system / Hugh Rosen, M. Germana Sanna, Pedro J. Gonzalez-Cabrera and Edward Roberts
Structural biology of the S1P₁ receptor / Michael A. Hanson and Robert Peach
Chemical and genetic tools to explore S1P biology / Stuart M. Cahalan
S1P control of endothelial integrity / Yuquan Xiong and Timothy Hla
Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen / Tal I. Arnon and Jason G. Cyster
Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule / Michael B.A. Oldstone and Hugh Rosen
Sphingosine-1-phosphate and central nervous system / Roland Martin and Mireia Sospedra
RORs in autoimmune disease / Mi Ra Chang, Hugh Rosen and Patrick R. Griffin.

Sphingosine-1-phosphate signaling in immunology and infectious diseases /

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