Techniques and methodological approaches in breast cancer research /
Saved in:
| Author / Creator: | Russo, Jose, 1942- author. |
|---|---|
| Imprint: | New York : Springer, 2014. ©2014 |
| Description: | 1 online resource. |
| Language: | English |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11085156 |
| Summary: | This volume explores the myriad of techniques and methodological approaches that are being used innbsp;breast cancer research. The authors critically evaluate of the advantages and disadvantages of current methodologies,nbsp;starting with the tools available for understandingnbsp;the architecture of the human breast, includingnbsp;its tissue and cellular composition.nbsp;The volume discussesnbsp;the importance ofnbsp;functional studies in breast cancer research, especially with the help ofnbsp;laser capture microdissection, which allows the separation of small amounts of tissue, as well as specific cells, for biochemical analysis. In addition, the authors address methodologies including stem cell separation, which has helped in significantly understanding their role in normal breast development, but also further thenbsp;understanding of breastnbsp;cancer and its therapeutic management. The use of in vitro techniques and established cell lines for mechanistic studies innbsp;chemotherapeutic approaches have been invaluable will be discussed.nbsp;Imaging techniquesnbsp;for evaluating in vitro and in vivo behavior of normal and cancerous breast tissue will be explored, as itnbsp;providesnbsp;a betternbsp;understanding of the physiopathology of cancer. The volume will also discuss the molecular analysis of gene function in breast cancernbsp;through the transcriptomic and epigenomic profile. More importantly, thenbsp;advancementnbsp;of more refined techniques innbsp;sequencing will be covered.nbsp;This monograph will be a comprehensive, authoritative and timely, as itnbsp;addresses the emerging approaches used in breast cancer research. |
|---|---|
| Item Description: | Includes index. |
| Physical Description: | 1 online resource. |
| ISBN: | 9781493907182 1493907182 1493907174 9781493907175 |