Lipid nanoparticles : production, characterization and stability /
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| Imprint: | Cham : Springer, [2014] ©2015 |
|---|---|
| Description: | 1 online resource (ix, 97 pages) : illustrations (some color). |
| Language: | English |
| Series: | SpringerBriefs in Pharmaceutical Science & Drug Development, 1864-8118 SpringerBriefs in pharmaceutical science & drug development, |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11087545 |
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| 245 | 0 | 0 | |a Lipid nanoparticles : |b production, characterization and stability / |c Rohan Shah, Daniel Eldridge, Enzo Palombo, Ian Harding. |
| 264 | 1 | |a Cham : |b Springer, |c [2014] | |
| 264 | 4 | |c ©2015 | |
| 300 | |a 1 online resource (ix, 97 pages) : |b illustrations (some color). | ||
| 336 | |a text |b txt |2 rdacontent |0 http://id.loc.gov/vocabulary/contentTypes/txt | ||
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| 490 | 1 | |a SpringerBriefs in Pharmaceutical Science & Drug Development, |x 1864-8118 | |
| 504 | |a Includes bibliographical references. | ||
| 588 | 0 | |a Online resource; title from PDF title page (SpringerLink, viewed September 11, 2014). | |
| 505 | 0 | |a Preface; Contents; 1 Introduction; Abstract ; 1.1 The Rationale of Introducing Colloidal Carriers; 1.2 Introduction to Colloidal Drug Carriers; 1.3 Lipid Nanoparticles: History and Scope; 1.4 Lipid Nanoparticles: Types; 1.4.1 Solid Lipid Nanoparticle (SLN); 1.4.2 Nanostructured Lipid Carrier (NLC); 1.4.3 Lipid Drug Conjugate (LDC); 1.4.4 Polymer-Lipid Hybrid Nanoparticle (PLN); References; 2 Composition and Structure; Abstract ; 2.1 Composition of Lipid Nanoparticles; 2.1.1 Lipids; 2.1.2 Surfactants; 2.1.3 Other Agents; 2.2 Structure of Solid Lipid Nanoparticles. | |
| 505 | 8 | |a 2.2.1 Drug-Enriched Shell Model2.2.2 Drug-Enriched Core Model; 2.2.3 Solid Solution Model; 2.3 Structure of Nanostructured Lipid Carriers; 2.3.1 NLC Type I or "Imperfect Crystal" Type; 2.3.2 NLC Type II or "Multiple" Type; 2.3.3 NLC Type III or "Amorphous" Type; 2.4 Conclusions; References; 3 Production Techniques; Abstract ; 3.1 General Considerations; 3.2 Production of Lipid Nanoparticles; 3.2.1 High Pressure Homogenization; 3.2.1.1 Hot Homogenization; 3.2.1.2 Cold Homogenization; 3.2.2 Microemulsion Technique; 3.2.3 Microwave-Assisted Microemulsion Technique; 3.2.4 Solvent Evaporation. | |
| 505 | 8 | |a 3.2.5 Double Emulsion3.2.6 Solvent Diffusion; 3.2.7 Solvent Injection (or Displacement); 3.2.8 High Shear Homogenization andor Ultrasound; 3.2.9 Membrane Contactor Method; 3.2.10 Supercritical Fluid Extraction of Emulsions; 3.2.11 Coacervation Technique; 3.2.12 Phase Inversion Temperature Technique; 3.3 Conclusions; References; 4 Characterization; Abstract ; 4.1 Particle Size; 4.1.1 Photon Correlation Spectroscopy; 4.1.2 Laser Diffraction; 4.1.3 Field-Flow Fractionation; 4.1.4 Other Techniques; 4.2 Particle Morphology and Ultrastructure; 4.2.1 Transmission Electron Microscopy. | |
| 505 | 8 | |a 4.2.2 Scanning Electron Microscopy4.2.3 Atomic Force Microscopy; 4.3 Surface Charge; 4.4 Crystallinity and Polymorphism; 4.4.1 Differential Scanning Calorimetry; 4.4.2 X-ray Diffraction; 4.4.3 Small Angle X-ray Scattering; 4.5 Co-existence of Addition Colloidal Structures and Interaction with Incorporated Drugs; 4.5.1 Nuclear Magnetic Resonance; 4.5.2 Electron Spin Resonance; 4.6 Conclusions; References; 5 Physicochemical Stability; Abstract ; 5.1 General Considerations; 5.2 Stabilization Mechanisms; 5.2.1 Electrostatic Stabilization; 5.2.2 Steric Stabilization; 5.3 Destabilization Mechanisms. | |
| 505 | 8 | |a 5.3.1 Physical Stability5.3.1.1 Dispersion Modifications; 5.3.1.2 Lipid Modifications; 5.3.2 Chemical Stability; 5.3.2.1 Drug Stability; 5.3.2.2 Phospholipid Stability; 5.3.2.3 Lipid Stability; 5.4 Stability Measurements; 5.4.1 Physical Stability; 5.4.1.1 Modification of Size; 5.4.1.2 Modification of Zeta Potential; 5.4.1.3 Modification of Crystallinity and Polymorphism; 5.4.1.4 Optical Analysis by Turbiscan® Lab; 5.4.2 Chemical Stability; 5.5 Optimization of Stability; 5.5.1 Physical Stability; 5.5.1.1 Steric Stabilization; 5.5.1.2 Electrostatic Stabilization. | |
| 520 | |a ?What are lipid nanoparticles? How are they structured? How are they formed What techniques are best to characterize them? How great is their potential as drug delivery systems? These questions and more are answered in this comprehensive and highly readable work on lipid nanoparticles. This work sets out to provide the reader with a clear and?understandable?understanding of the current practices in formulation, characterization and drug delivery of lipid nanoparticles. A?comprehensive description of?the current understanding of synthesis, characterization, stability optimization and drug incor. | ||
| 650 | 0 | |a Nanoparticles. |0 http://id.loc.gov/authorities/subjects/sh85089689 | |
| 650 | 0 | |a Lipids. |0 http://id.loc.gov/authorities/subjects/sh85077296 | |
| 650 | 0 | |a Lipids |x Biotechnology. | |
| 650 | 1 | 4 | |a Biomedicine. |
| 650 | 2 | 4 | |a Pharmaceutical Sciences/Technology. |
| 650 | 2 | 4 | |a Biotechnology. |
| 650 | 2 | 4 | |a Lipidology. |
| 650 | 7 | |a TECHNOLOGY & ENGINEERING |x Engineering (General) |2 bisacsh | |
| 650 | 7 | |a TECHNOLOGY & ENGINEERING |x Reference. |2 bisacsh | |
| 650 | 7 | |a Lipids. |2 fast |0 (OCoLC)fst00999367 | |
| 650 | 7 | |a Lipids |x Biotechnology. |2 fast |0 (OCoLC)fst00999370 | |
| 650 | 7 | |a Nanoparticles. |2 fast |0 (OCoLC)fst01032624 | |
| 655 | 4 | |a Electronic books. | |
| 700 | 1 | |a Shah, Rohan, |e author. |0 http://id.loc.gov/authorities/names/n2015180917 |1 http://viaf.org/viaf/4940149068623765730000 | |
| 776 | 0 | 8 | |i Print version: |a Shah, Rohan. |t Lipid Nanoparticles : Production, Characterization and Stability. |d Dordrecht : Springer, ©2014 |z 9783319107103 |
| 830 | 0 | |a SpringerBriefs in pharmaceutical science & drug development, |x 1864-8118 | |
| 856 | 4 | 0 | |u http://link.springer.com/10.1007/978-3-319-10711-0 |y SpringerLink |
| 903 | |a HeVa | ||
| 929 | |a eresource | ||
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| 928 | |t Library of Congress classification |a RS201.N35 |l Online |c UC-FullText |u http://link.springer.com/10.1007/978-3-319-10711-0 |z SpringerLink |g ebooks |i 9899796 | ||