Dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cells : mathematical modeling and experimental observations /

Dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cells : mathematical modeling and experimental observations /

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Bibliographic Details
Author / Creator:Tavassoly, Iman, author.
Imprint:Cham : Springer, [2015]
©2015
Description:1 online resource : color illustrations.
Language:English
Series:Springer theses
Springer theses.
Subject:
Cell determination -- Mathematical models.
Apoptosis -- Mathematical models.
Cell determination -- Observations.
Apoptosis -- Observations.
Cancer cells.
Apoptosis.
Cancer cells.
Cell determination.
Observations.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11091845
Hidden Bibliographic Details
ISBN:9783319149622
3319149628
331914961X
9783319149615
9783319149615
Digital file characteristics:text file PDF
Notes:Includes bibliographical references.
Online resource; title from PDF title page (EBSCO, viewed February 23, 2015).
Summary:This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative℗ℓfluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.
Other form:Printed edition: 9783319149615
Standard no.:10.1007/978-3-319-14962-2

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