Resistance of cancer cells to CTL-mediated immunotherapy /

Resistance of cancer cells to CTL-mediated immunotherapy /

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Bibliographic Details
Imprint:	Cham : Springer, 2015.
Description:	1 online resource (xiv, 353 pages) : illustrations (some color).
Language:	English
Series:	Resistance to targeted anti-cancer therapeutics, 2196-5501 ; volume 7 Resistance to targeted anti-cancer therapeutics ; volume 7.
Subject:	Drug resistance in cancer cells. Cancer -- Immunotherapy. Cancer -- Immunotherapy. Drug resistance in cancer cells. Immunotherapy, Adoptive -- contraindications. T-Lymphocytes, Cytotoxic -- immunology.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11094643

Hidden Bibliographic Details
Other authors / contributors:	Bonavida, Benjamin, editor. Chouaib, S. (Salem), editor.
ISBN:	9783319178073 3319178075 3319178067 9783319178066 9783319178066
Digital file characteristics:	text file PDF
Notes:	Includes index. Online resource; title from PDF title page (SpringerLink, viewed June 24, 2015).
Summary:	This book, written by leading investigators, brings together the latest knowledge about key aspects of the most rapidly progressing fields of tumor escape and tumor resistance to CTL. Readers will benefit from a collection of outstanding surveys that cover some factors regulating resistance to CTL cytotoxicity, the influence of tumor microenvironment, and the resistance to death ligands, mediated apoptosis, and means to reverse resistance. This remarkable volume also emphasizes the future directions that may lead to the design of more innovative, refined, and integrative immunotherapies to target tumor plasticity and heterogeneity, and help to overcome the inherent limitations of current treatments. By providing a broad scope of innovative concepts in the burgeoning field of cancer biology and immunotherapy, this volume will be of exceptional interest and a valuable reference for scientists, clinicians, health professionals, and biopharmaceutical companies working in the field of cancer immunotherapy.
Other form:	Printed edition: 9783319178066
Standard no.:	10.1007/978-3-319-17807-3

Description
Summary:	This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.
Item Description:	Includes index.
Physical Description:	1 online resource (xiv, 353 pages) : illustrations (some color).
ISBN:	9783319178073 3319178075 3319178067 9783319178066
ISSN:	2196-5501 ;