Intercellular communication in cancer /

Intercellular communication in cancer /

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Bibliographic Details
Imprint:Dordrecht : Springer, 2015.
Description:1 online resource.
Language:English
Subject:
Cancer cells.
Cell interaction.
Cell junctions.
Cancer cells.
Cell interaction.
Cell junctions.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11096658
Hidden Bibliographic Details
Other authors / contributors:Kandouz, Mustapha, editor.
ISBN:9789401773805
9401773807
9789401773799
9401773793
9789401773799
Digital file characteristics:text file PDF
Notes:Includes bibliographical references and index.
Online resource; title from PDF title page (EBSCO, viewed January 20, 2016).
Summary:Cells are by nature compelled to live in groups. They develop dependence over signaling cues received from their microenvironment, in particular from other cells, whether of their own ℓ́ℓkindℓ́ℓ or of a different type. Therefore, communicating with these cells is a critical aspect of their behavior and fate, as they live and die normally or as they undergo disease-related pathological changes, with dramatic repercussions. In℗ℓthis book,℗ℓwe have asked expert researchers in the field of Intercellular Communication in Cancer to provide chapters on different aspects of interaction between neighboring cells, in the context of cancer diseases.℗ℓWe have specifically focused our efforts on membrane-to-membrane contact-based rather than growth factors-mediated modes of intercellular communications. The contributing authors provide an extensive overview of their respective area of specialization, with an in-depth discussion of the molecular mechanisms of cell-cell interactions, the impact on tumor progression and response to therapies, as well as the cancer diagnostic value of this scientific information. This book℗ℓaims to introduce essential aspects of the normal and pathological cellular fate and homeostasis to both scientists and clinicians, and also to provide established researchers with an update on the novelties and future directions this expanding field is witnessing.
Other form:Printed edition: 9789401773799
Standard no.:10.1007/978-94-017-7380-5
Table of Contents:
  • Preface
  • Contributors.-¡Beyond the channel: Role of connexins in regulating normal and cancerous processes in the mammary gland.-¡¡¡¡ Connexins: Bridging the gap between the tumor microenvironment and cancer cell communication in brain tumors
  • MicroRNA and Gap Junctions in Glioblastoma cells: Implications for cellular therapy.-¡Dynamic regulation of adherens junctions: implication in cell differentiation and tumor development
  • Cadherin-based cell-cell adhesions: adhesion structure, signalling and computational modeling.-¡E-cadherin/catenin complex modulations in human oral cancer.-¡¡¡¡¡ Tumor-derived exosomes in metastasis signaling and implications.-¡¡¡¡¡ Tunneling Nanotubes: Intercellular conduits for direct cell-to-cell communication in cancer.-¡Cell-Cell Fusion, Chemotaxis and Metastasis.-¡Role of the family of Ephs and Ephrins in non-junctional cell-cell communication in cancer.-¡Computational approaches to modeling of molecular interactions in multicellular systems.-¡Contact Normalization or Escape from the Matrix.-¡Intercellular communication, the tumor microenvironment, and tumor progression.-¡Index.

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