Molecular profiling : methods and protocols /

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Bibliographic Details
Imprint:	New York, N.Y. : Humana : Springer [distributor], ©2012.
Description:	1 online resource (xiii, 447 pages) : illustrations (some color)
Language:	English
Series:	Methods in molecular biology, 1940-6029 ; 823 Methods in molecular biology (Clifton, N.J.) ; v. 823.
Subject:	Molecular diagnosis -- Laboratory manuals. Pathology, Molecular -- Laboratory manuals. Microarray Analysis. Genetic Techniques. Pathology. Molecular Biology. Disease. Clinical Laboratory Techniques. Microchip Analytical Procedures. Investigative Techniques Biochemistry. Genetics. Medicine. Chemistry Techniques, Analytical. Chemistry. Analytical, Diagnostic and Therapeutic Techniques and Equipment Health Occupations. Biological Science Disciplines. Biology. Natural Science Disciplines. Disciplines and Occupations Molecular Diagnostic Techniques. Pathology, Molecular. Tissue Array Analysis. Neoplasms. Molecular diagnosis. Pathology, Molecular. Laboratory manuals.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11120241

Hidden Bibliographic Details
Other authors / contributors:	Espina, Virginia. Liotta, L. A. (Lance A.)
ISBN:	9781603272162 160327216X 9781603272155 1603272151
Digital file characteristics:	text file
Notes:	Includes bibliographical references and index. English. Print version record.
Summary:	The next revolution in molecular medicine is the application of molecular profiling to individualized patient therapy. Molecular profiling technology has advanced dramatically, particularly in the field of cancer tissue biomarkers. It is now possible to gather complex genomic and proteomic information from a routine clinical needle biopsy or surgical specimen. In Molecular Profiling: Methods and Protocols, expert researchers in the field focus on the entire process from discovery to commercialization, with practical guides that are not limited to experimental methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, as well as essays and guidelines for grants, patents, and commercialization of products related to molecular profiling. Authoritative and practical, Molecular Profiling: Methods and Protocols seeks to aid scientists in understanding the latest advancements in genomics, proteomics, imagining, and bioinformatics.
Other form:	Print version: Molecular profiling. Totowa, N.J. : Humana ; London : Springer [distributor], 2011 9781603272155
Standard no.:	10.1007/978-1-60327-216-2

Table of Contents:

Tumor staging and grading: A primer
Clinical trial design in the age of molecular profiling
Personalized medicine: ethics for clinical trials
Reduction of preanalytical variability in specimen procurement for molecular profiling
The human side of cancer biobanking
Introduction to genomics
Genomic profiling: cDNA arrays and oligoarrays
Genome-wide methylation profiling in archival formalin-fixed paraffin-embedded tissue samples
An overview of microRNA methods: expression profiling and target identification
Antibody validation by western blotting
Laser capture microdissection: Arcturus(XT) infrared capture and UV cutting methods
Antibody microarrays: Analysis of cystic fibrosis
Tissue microarrays as a tool in the discovery and validation of predictive biomarkers
Reverse-phase protein microarrays
Serum low-molecular-weight protein fractionation for biomarker discovery
Mass spectrometry-based biomarker discovery
Mitochondrial proteome: toward the detection and profiling of disease associated alterations
Adult neural stem cells: Isolation and propagation
Evanescent-wave field imaging: An introduction to total internal reflection fluorescence microscopy
Construction and hyperspectral imaging of quantum dot lysate arrays
Microarray data analysis: Comparing two population means
Bioinformatics/biostatistics: microarray analysis
Structure-based functional design of drugs: From target to lead compound
Personalized medicine: Changing the paradigm of drug development
Grant writing tips for translational research
Inventions and patents: a practical tutorial
Regulatory approval pathways for molecular diagnostic technology
Small business development for molecular diagnostics.

Molecular profiling : methods and protocols /

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