Cancer on trial : oncology as a new style of practice /
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| Author / Creator: | Keating, Peter, 1953- |
|---|---|
| Imprint: | Chicago : University of Chicago Press, ©2012. |
| Description: | 1 online resource (xviii, 456 pages) : illustrations |
| Language: | English |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11124003 |
Table of Contents:
- From "nonentity" to global network: the rise of a new style of biomedical practice
- An early career in clinical oncology
- About this book
- A capsule history of cancer clinical trials
- Cancer clinical trials as a new style of practice
- The protocol
- Before there were trials
- Cancer hospitals and cancer institutes
- Diagnosing cancer
- Treating cancer
- Prognosticating cancer
- Testing therapies
- The emergence of clinical cancer research (1955-66)
- A landmark clinical trial
- Curing leukemia: the vamp trial
- A collective undertaking
- The elements of innovation
- What about the patients?
- The collective turn: cooperative groups as epistemic organizations
- Assembling the US cooperative system
- Screening for drugs: from mice to humans
- Tinkering with the cooperative group structure
- Meanwhile in Europe
- Clinical trial statistics
- What is a random sample?
- What is statistical significance?
- Statisticians, statistics, and early cooperative clinical trials
- Statisticians at the NIH
- Statisticians in Paris
- Fabricating the tools of the trade
- Controversial methods
- The emergence of the phase system
- Criticism and the redefinition of clinical cancer trials as an autonomous form of research
- Clinical cancer research under fire
- The reorganization of screening and clinical trials in the United States
- Surgery and radiotherapy in the cooperative groups
- An avalanche of numbers from the new style of practice (1965-89)
- A web of trials
- Breast cancer and its trials
- The lessons of the breast cancer trials
- The emergence of combination chemotherapy
- The multiple meanings of breast cancer trials
- Statisticians, data centers, and the organization of large-scale clinical trials
- Centers of calculation: us statisticians and the data center
- The mechanics of data production
- Meanwhile in Europe, take two
- Back in the USA: group statisticians and NCI statisticians
- Insiders' dissent: the randomization debate
- A relational space of substances and regimens
- The clinical evaluation of substances
- Screening substances: the animal screen
- Procuring compounds
- Oncopolitics? reshaping collaborative research
- Centralization or coordination? the European debate
- Clinical trials as clinical research: the US debate
- Oncology in the community
- Targeted therapy, targeted trials (1990-2006)
- Second interlude: molecular biology and oncogenes
- The rise of molecular biology
- Cancer and molecular biology: 1960-80
- The clinical isolation of human oncogenes
- Oncogenes and oncoproteins since 1982
- Magic bullets? the Gleevec trials
- Molecular biology and targeted substances
- The trials of a targeted therapy
- Where did Gleevec come from?
- Monitoring data, managing risks
- A medical oncologist and his patients
- Patients and activists
- Targeted therapy and clinical cancer research
- Introduction: molecular biology and translational research
- Molecular biology and the US cooperative groups
- The reorganization of the drug discovery process and the transformation of the NCI screen
- Clinical trials in a targeted age
- More oncopolitics
- Looking back and looking forward
- The observational alternative to clinical cancer trials
- Comparative effectiveness and clinical trials.