Ubiquitin family modifiers and the proteasome : reviews and protocols /

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Bibliographic Details
Imprint:New York : Humana Press, ©2012.
Description:1 online resource (xvi, 666 pages)
Language:English
Series:Methods in molecular biology, 1064-3745 ; 832
Methods in molecular biology (Clifton, N.J.) ; v. 832.
Subject:
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11125183
Hidden Bibliographic Details
Other authors / contributors:Dohmen, R. Jürgen.
Scheffner, Martin.
ISBN:9781617794742
1617794740
1617794732
9781617794735
9781617794735
Digital file characteristics:text file PDF
Notes:Includes index.
Includes bibliographical references and index.
English.
Summary:The ubiquitin-proteasome system (UPS) and ubiquitin-related modifiers are not only involved in cellular protein quality control but also in the regulation of many fundamental cellular processes/pathways as well as in their disease-relevant aberrations. Ubiquitin Family Modifiers and Proteasome: Reviews and Protocols presents both novel developments in UPS research and important methods related to the main recent advances in the field of ubiquitin family modifiers. Divided into five convenient sections, this volume focuses on the enzymology and substrate identification of ubiquitin family modifiers, the recognition and chain formation of these modifiers, the analysis of proteasome biogenesis and function, protein quality control, and finally the use of small molecules and strategies to study or manipulate the function of the UPS and of ubiquitin family modifiers, respectively. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Ubiquitin Family Modifiers and Proteasome: Reviews and Protocols will be of great use to investigators and students engaged in both basic and applied research in life sciences.
Other form:Printed edition: 9781617794735
Standard no.:10.1007/978-1-61779-474-2
Description
Summary:

The ubiquitin-proteasome system (UPS) and ubiquitin-related modifiers are not only involved in cellular protein quality control but also in the regulation of many fundamental cellular processes/pathways as well as in their disease-relevant aberrations. Ubiquitin Family Modifiers and Proteasome: Reviews and Protocols presents both novel developments in UPS research and important methods related to the main recent advances in the field of ubiquitin family modifiers. Divided into five convenient sections, this volume focuses on the enzymology and substrate identification of ubiquitin family modifiers, the recognition and chain formation of these modifiers, the analysis of proteasome biogenesis and function, protein quality control, and finally the use of small molecules and strategies to study or manipulate the function of the UPS and of ubiquitin family modifiers, respectively. Written in the highly successful Methods in Molecular Biology(tm) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easily accessible, Ubiquitin Family Modifiers and Proteasome: Reviews and Protocols will be of great use to investigators and students engaged in both basic and applied research in life sciences.

Item Description:Includes index.
Physical Description:1 online resource (xvi, 666 pages)
Bibliography:Includes bibliographical references and index.
ISBN:9781617794742
1617794740
1617794732
9781617794735
ISSN:1064-3745
;