Growth factors and receptors : a practical approach /
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| Imprint: | Oxford [England] ; New York : Oxford University Press, 1998. |
|---|---|
| Description: | 1 online resource (xxii, 266 pages) : illustrations. |
| Language: | English |
| Series: | Practical approach series ; 194 Practical approach series ; 194. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11127865 |
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| 049 | |a MAIN | ||
| 050 | 4 | |a QP552.G76 |b G7445 1998eb | |
| 060 | 4 | |a 1998 G-931 | |
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| 072 | 7 | |a SCI |x 072000 |2 bisacsh | |
| 245 | 0 | 0 | |a Growth factors and receptors : |b a practical approach / |c edited by Ian A. McKay and Kenneth D. Brown. |
| 260 | |a Oxford [England] ; |a New York : |b Oxford University Press, |c 1998. | ||
| 300 | |a 1 online resource (xxii, 266 pages) : |b illustrations. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Practical approach series ; |v 194 | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |6 880-01 |a Intro; Contents; List of contributors; Abbreviations; 1. Engineered growth factors and receptors, and their applications; 1. Introduction; Known growth factors and receptors; Modes of factor-receptor interaction; 2. Applications of engineered growth factors and receptors; 3. Principal methods for engineering growth factors and their receptors; Mutagenesis; Formation of chimeric proteins; Manufacture of alternative ligands and receptors; 4. Design of engineered growth factors and receptors; DNA sequence of factor or receptor to be engineered. | |
| 505 | 8 | |a Analysis of existing DNA sequence for useful restriction sitesDesign of wholly synthetic growth factors and receptors; 5. Expression of DNAs encoding growth factors or receptors; Deciding on an expression system; Microbial expression; In vitro expression; Eukaryotic gene expression; Acknowledgements; References; 2. Engineering of novel neurotrophins; 1. Introduction; 2. Structure-function analyses of neurotrophins; 3. Site-directed mutagenesis; Kunkel method; PCR-based mutagenesis; 4. Expression of recombinant protein; COS cell expression; Baculovirus expression. | |
| 520 | |a Growth factors are extra-cellular molecules that interact with receptors on the cell surface to initiate a sequence of events culminating in transcription of DNA prior to cell division. Disturbances in the production of growth factors or the sensitivity of their receptors are important in tumour growth. Therefore, there is much interest in engineering both growth factors and their receptors to intervene in cancer. This book describes a variety of techniques for theengineering, analysis, definition of function and detection of gene expression of growth factors and their receptors. A number of p. | ||
| 650 | 0 | |a Growth factors |v Laboratory manuals. | |
| 650 | 0 | |a Growth factors |x Receptors |v Laboratory manuals. | |
| 650 | 0 | |a Genetic engineering |v Laboratory manuals. | |
| 650 | 0 | |a Gene therapy |x Research |v Laboratory manuals. | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Developmental Biology. |2 bisacsh | |
| 650 | 7 | |a Gene therapy |x Research. |2 fast |0 (OCoLC)fst00939641 | |
| 650 | 7 | |a Genetic engineering. |2 fast |0 (OCoLC)fst00940027 | |
| 650 | 7 | |a Growth factors. |2 fast |0 (OCoLC)fst00948607 | |
| 650 | 7 | |a Growth factors |x Receptors. |2 fast |0 (OCoLC)fst00948612 | |
| 650 | 1 | 2 | |a Growth Substances |v Laboratory Manuals. |
| 650 | 2 | 2 | |a Genetic Therapy |v Laboratory Manuals. |
| 650 | 2 | 2 | |a Receptors, Growth Factor |v Laboratory Manuals. |
| 655 | 4 | |a Electronic books. | |
| 655 | 7 | |a Laboratory manuals. |2 fast |0 (OCoLC)fst01920776 | |
| 700 | 1 | |a McKay, Ian |q (Ian A.) |0 http://id.loc.gov/authorities/names/n92091102 | |
| 700 | 1 | |a Brown, Kenneth D. | |
| 776 | 0 | 8 | |i Print version: |t Growth factors and receptors. |d Oxford [England] ; New York : Oxford University Press, 1998 |z 0199636478 |z 019963646X |w (DLC) 98009879 |w (OCoLC)38249246 |
| 830 | 0 | |a Practical approach series ; |v 194. |0 http://id.loc.gov/authorities/names/n84709852 | |
| 880 | 8 | |6 505-01/(S |a Construction and expression of EGF/TGFα chimeras. | |
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| 928 | |t Library of Congress classification |a QP552.G76 G7445 1998eb |l Online |c UC-FullText |u https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=e000xna&AN=98486 |z eBooks on EBSCOhost |g ebooks |i 12220741 | ||