Suicide gene therapy : methods and reviews /

Suicide gene therapy : methods and reviews /

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Bibliographic Details
Imprint:Totowa, N.J. : Humana Press, ©2004.
Description:1 online resource (xiv, 555 pages) : illustrations (some color)
Language:English
Series:Methods in molecular medicine, 1543-1894 ; 90
Methods in molecular medicine ; 90.
Subject:
Cancer -- Gene therapy.
Neoplasms -- therapy.
Genetic Therapy -- methods.
Genes, Transgenic, Suicide.
Cancer -- Gene therapy.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11128336
Hidden Bibliographic Details
Other authors / contributors:Springer, Caroline J.
ISBN:9781592594290
1592594298
0896039714
9780896039711
1280842997
9781280842993
9786610842995
661084299X
Notes:Includes bibliographical references and index.
English.
Print version record.
Summary:Suicide gene therapy has become a major element in anticancer gene therapy and holds great promise for the future. In Suicide Gene Therapy: Methods and Reviews, prominent researchers and clinicians comprehensively detail the theory and practice of this exciting and elegant therapeutic approach. In their multidisciplinary treatment, the authors cover all the major aspects of suicide gene therapy, including the design and use of vectors in gene transduction, various enzyme and prodrug systems, the mechanistic analysis of the bystander effect, the design and synthesis of prodrugs, the immunological implications, and its clinical impact. They also describe and expound upon all the cutting-edge methods needed to explore, study, and advance understanding of the basic biology underlying gene therapy. Each fully tested method includes step-by-step instructions, a discussion of the principle behind the technique, equipment and reagent lists, tips on troubleshooting and avoiding pitfalls, and notes on the interpretation and use of results. Authoritative and up-to-date, Suicide Gene Therapy: Methods and Reviews not only summarizes our knowledge of suicide gene therapy today, but also provides the experimental means to advance its future development and therapeutic applications.
Other form:Print version: Suicide gene therapy. Totowa, N.J. : Humana Press, ©2004 0896039714
Standard no.:9781592594290
10.1385/1592594298.
Table of Contents:
  • Preface
  • Contributors
  • 1. Introduction to the Background, Principles, and State of the Art in Suicide Gene Therapy
  • 2. Introduction to Vectors for Suicide Gene Therapy
  • 3. Construction of VNP20009: A Novel, Genetically Stable Antibiotic-Sensitive Strain of Tumor-Targeting Salmonella for Parenteral Administration in Humans
  • 4. Nonreplicating DNA Viral Vectors for Suicide Gene Therapy: The Adenoviral Vectors
  • 5. Replication-Selective Oncolytic Adenoviruses
  • 6. Retroviral Vectors for Suicide Gene Therapy
  • 7. Nonviral Liposomes
  • 8. Peptide- and Polymer-Based Gene Delivery Vehicles
  • 9. Design of Prodrugs for Suicide Gene Therapy
  • 10. Cytochrome P450-Based Gene Therapies for Cancer
  • 11. Tumor Sensitization to Purine Analogs by E. coli PNP
  • 12. Enzyme--Prodrug Systems: Carboxylesterase/CPT-11
  • 13. Enzyme--Prodrug Systems: Thymidine Phosphorylase/5'-Deoxy-5-Fluorouridine
  • 14. Methods to Improve Efficacy in Suicide Gene Therapy Approaches: Targeting Prodrug-Activating Enzymes Carboxypeptidase G2 and Nitroreductase to Different Subcellular Compartments
  • 15. Extracellular [beta]-Glucuronidase for Gene-Directed Enzyme--Prodrug Therapy
  • 16. Enhancement of Suicide Gene Prodrug Activation by Random Mutagenesis
  • 17. Combination Suicide Gene Therapy
  • 18. Immune Response to Suicide Gene Therapy
  • 19. Targeting Cancer With Gene Therapy Using Hypoxia as a Stimulus
  • 20. Radiation-Activated Antitumor Vectors
  • 21. In Vitro and In Vivo Models for the Evaluation of GDEPT: Quantifying Bystander Killing in Cell Cultures and Tumors
  • 22. Suicide Gene Therapy in Liver Tumors
  • 23. Clinical Trials With GDEPT: Cytosine Deaminase and 5-Fluorocytosine
  • 24. The Nitroreductase/CB 1954 Enzyme--Prodrug System
  • 25. Side Effects of Suicide Gene Therapy
  • 26. Antibody-Directed Enzyme--Prodrug Therapy
  • 27. Bioreductive Prodrugs for Cancer Therapy
  • Index

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