New vaccine development : establishing priorities. Volume II, Diseases of importance in Developing Countries /

New vaccine development : establishing priorities. Volume II, Diseases of importance in Developing Countries /

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Bibliographic Details
Imprint:Washington, D.C. : National Academy Press, 1986.
Description:1 online resource (1 volume)
Language:English
Subject:
Vaccines -- Research -- Government policy.
Vaccination -- United States.
Vaccination -- Developing countries.
Health Planning.
Communicable Disease Control.
Vaccines -- supply & distribution.
Developing Countries.
Health Policy.
Vaccination.
United States.
Developing countries.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11133664
Hidden Bibliographic Details
Varying Form of Title:Diseases of importance in Developing Countries
Other authors / contributors:Institute of Medicine (U.S.). Committee on Issues and Priorities for New Vaccine Development.
National Institute of Allergy and Infectious Diseases (U.S.)
ISBN:030956820X
9780309568203
Notes:Prepared for the National Institute of Allergy and Infectious Diseases.
Includes bibliographical references and indexes.
Print version record.
Other form:Print version: New vaccine development. Washington, D.C. : National Academy Press, 1986 0309036798
Table of Contents:
  • New Vaccine Development Establishing Priorities
  • Copyright
  • Acknowledgements
  • Preface
  • Abstract
  • Contents
  • Summary
  • SELECTION OF CANDIDATES
  • DETERMINATION OF HEALTH BENEFITS
  • Disease Burden Estimates
  • Infant Mortality Equivalence Values
  • Total Disease Burden Values
  • VACCINE CHARACTERISTICS
  • Predictions of Vaccine Development
  • Definition of Probable Vaccine Target Population
  • Treatment of Vaccine Utilization
  • Estimation of Time to Licensure, Time to Vaccine Adoption, and Delay of Vaccination Benefits: Discou ...
  • Estimation of Vaccine Preventable IllnessCalculation of Potential Health Benefits for Each Vaccine
  • Cost Calculations
  • INTERPRETATION OF RESULTS
  • FINDINGS, CONCLUSIONS, RECOMMENDATIONS
  • REFERENCE
  • 2 Priority Setting for Health-Related Investments: A Review of Methods
  • METHODS FOR PROJECT RANKING AND SELECTION
  • MULTIATTRIBUTE ACCOUNTING
  • MULTIATTRIBUTE SCORING
  • DECISION ANALYSIS WITH MULTIPLE OBJECTIVES
  • COST-EFFECTIVENESS AND COST-UTILITY ANALYSIS
  • BENEFIT-COST ANALYSIS
  • SELECTION OF AN APPROACH
  • ISSUES IN PROJECT RANKING METHODOLOGIESSources of Estimates
  • Sequential or “Lexicographicâ€? Methods
  • Interdependence Among Projects
  • The “Portfolioâ€? Question
  • SUMMARY
  • REFERENCES
  • 3 Overview of the Analytic Approach
  • METHOD
  • Calculation Procedures
  • INTERPRETATION OF RESULTS
  • GUIDELINES
  • Step 1
  • Step 2
  • SUMMARY
  • REFERENCE
  • 4 Comparison of Disease Burdens
  • ELEMENTS OF THE SYSTEM FOR COMPARING MORBIDITY AND MORTALITY BURDENS ARISING FROM VARIOUS DISEASES
  • Trade-Off Values
  • Expression of Morbidity and Mortality BurdensProcedures Used in Deriving Disease Estimates
  • Limitations of the Current Estimates
  • VALUE JUDGMENTS IN QUANTIFYING MORBIDITY AND MORTALITY
  • IME Perspective Used in This Study
  • The Effect of Adopting Other IME Perspectives
  • COMPARISON OF COSTS ASSOCIATED WITH DISEASES
  • Estimating Aggregate Direct Costs of Diseases in the Developing World
  • Estimating Costs for Diseases in Specific Countries or Regions
  • Indirect Costs
  • FINDINGS
  • LIMITATIONS OF THE PROPOSED SYSTEM
  • SUMMARY AND CONCLUSIONS
  • RECOMMENDATIONSREFERENCES
  • 5 Predictions on Vaccine Development
  • THE NEED FOR PREDICTIONS
  • SELECTION OF CANDIDATES
  • VACCINE CANDIDATES AND TARGET POPULATIONS
  • PREDICTIONS ON VACCINE DEVELOPMENT
  • Probability of Successful Development
  • Cost of Development
  • Time to Licensure
  • PREDICTIONS ON VACCINE CHARACTERISTICS
  • Efficacy
  • Adverse Reactions
  • Production Technology, Delivery Requirements, and Cost per Dose
  • Number of Doses and Route of Administration
  • CONCLUSIONS
  • REFERENCE

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