Synthetic vaccines /

Synthetic vaccines /

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Bibliographic Details
Imprint:San Diego, CA : Academic Press, ©2012.
Description:1 online resource (xiv, 260 pages).
Language:English
Series:Advances in Immunology ; 114
Advances in immunology ; 114.
Subject:
Synthetic vaccines.
Synthetic vaccines.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11148521
Hidden Bibliographic Details
Other authors / contributors:Melief, Cornelius J. M.
ISBN:9780123965486
0123965489
9780123972316
0123972310
Notes:Includes index.
Includes bibliographical references and index.
Summary:Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.
Table of Contents:
  • Contributors
  • Preface
  • 1. Nucleic Acid Adjuvants: Toward an Educated Vaccine
  • 1. A Short Vaccination History
  • 2. The Immune System as Sensory Tissue
  • 3. Why Some Vaccines Just Do Not Work
  • 4. Synergizing Innate Immune Stimuli
  • 5. Therapeutic Vaccination: Just a Shot Away?
  • 6. Toward the Integrated Response: Cross-Priming of Cytotoxic T Cell Immunity
  • 7. Conclusion
  • Acknowledgments
  • References
  • 2. Structure-Based Design for High-Hanging Vaccine Fruits
  • 1. Targets for Structural Vaccinology
  • 2. Stabilizing Antigens
  • 3. Engineering Immunogenicity and Immunodominance
  • 4. Focus on Domains
  • 5. Focus on Minimal Antigenic Site
  • 6. Natural Scaffolds
  • 7. Concluding Remarks
  • Acknowledgments
  • References
  • 3. Mechanisms of Peptide Vaccination in Mouse Models: Tolerance, Immunity, and Hyperreactivity
  • 1. Introduction
  • 2. Once Upon a Time
  • 3. Rules of Engagement
  • 4. Vaccine-Induced Hyper Reactivity
  • 5. The Hallmarks of Peptide Vaccination
  • Acknowledgments
  • References
  • 4. Experience with Synthetic Vaccines for Cancer and Persistent Virus Infections in Nonhuman Primates and Patients
  • 1. Introduction
  • 2. Vaccination of Cancer Patients
  • 3. Vaccination Against HIV-1
  • 4. Vaccination Strategies
  • 5. Synthetic Long Peptide Vaccine
  • 6. Immune Escape
  • 7. Clinical Studies with Peptide Vaccines in Cancer Patients
  • 8. Synthetic Peptide Vaccination in Nonhuman Primates
  • 9. Long Peptides as Prophylactic Vaccines
  • 10. Improvement of Long Peptide Vaccination by Combination of Synthetic Vaccines with Other Cancer Treatment Modalities
  • 11. Immunopharmacology
  • 12. Hurdles to Successful Therapeutic Vaccination
  • 13. Conclusions and Perspective
  • Acknowledgments
  • References
  • 5. Malaria Vaccine Development Using Synthetic Peptides as a Technical Platform
  • 1. Introduction
  • 2. Peptide Synthesis
  • 3. Preerythrocytic P. falciparum Synthetic Vaccines
  • 4. Erytrocytic Synthetic Vaccines
  • 5. P. vivax Synthetic Vaccine
  • 6. Future Developments
  • Acknowledgments
  • References
  • 6. Enhancing Cancer Immunotherapy by Intracellular Delivery of Cell-Penetrating Peptides and Stimulation of Pattern-Recognition Receptor Signaling
  • 1. Introduction
  • 2. Adoptive Cell Therapy: History and Recent Progresses
  • 3. APC-Based Vaccines: The First FDA Approved Drug for Prostate Cancer
  • 4. Tumor Antigens Recognized by Tumor-Reactive T Cells
  • 5. Current Progresses of Synthetic Peptide Vaccines
  • 6. Enhancing Antitumor Immunity by Intracellular Delivery of Peptides into DCs
  • 7. Enhancing Immune Responses and Blocking Immune Suppression by Stimulation of Innate Immune Receptors
  • 8. Conclusions
  • Acknowledgments
  • References
  • 7. TLR Ligand-Peptide Conjugate Vaccines: Toward Clinical Application
  • 1. Introduction
  • 2. Targeting and DC Maturation
  • 3. Synthetic Peptide Vaccination
  • 4. Conjugation of Antigen to TLR Ligands
  • 5. Future Directions
  • References
  • 8. Behavior and Function of Tissue-Resident Memory T cells
  • 1. Introduction
  • 2. Regulation of Tissue-Resident Memory T Cells
  • 3. Potential Functions of Tissue-Resident Memory T Cells
  • 4. Tissue-Resident Memory T Cells and Vaccination
  • 5. Concluding remarks
  • References
  • 9. Rational Design of Vaccines: Learning from Immune Evasion Mechanisms of Persistent Viruses and Tumors
  • 1. Immune Evasion by Persistent Viruses and Tumors
  • 2. Immune Evasion of Antigen Presentation Pathways
  • 3. Immune Evasion of Costimulatory Pathways
  • 4. Immune Evasion and the Interferon System
  • 5. Immune Evasion and Induction of Inhibitory Cytokines
  • 6. Immune Evasion and Chemokines
  • 7. Coping With Immune Evasion: Implications for Rational Design of Vaccines and Imrhunotherapy
  • 8. Future Prospects
  • Acknowledgments
  • References
  • Index
  • Contents of Recent Volumes

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