Antibody drug discovery /

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Bibliographic Details
Imprint:	London : Imperial College Press, 2012.
Description:	1 online resource (xv, 473 pages) : illustrations (some color)
Language:	English
Series:	Molecular medicine and medicinal chemistry ; v. 4 Molecular medicine and medicinal chemistry ; v. 4.
Subject:	Immunoenzyme technique. Antibody-drug conjugates. Immunology -- Technique. Drug development. Pharmaceutical biotechnology. Antibody-drug conjugates. Drug development. Immunoenzyme technique. Immunology -- Technique. Pharmaceutical biotechnology. Electronic books.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11148947

Hidden Bibliographic Details
Other authors / contributors:	Wood, Clive R.
ISBN:	9781848166295 184816629X 1848166281 9781848166288
Notes:	Includes bibliographical references and index.
Summary:	Monoclonal antibodies have become important treatments for cancer, inflammation and a wide range of other diseases, representing an increasing share of the most successful pharmaceutical markets. The technologies to discover these drugs have been developed by select centers of excellence in industry and academia, and are continually being fine tuned in the race to identify the best antibody-based drug candidates and accelerate their paths to patients. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field and to offer specialized perspectives to established researchers. The chapters set into context the significance of key developments and important considerations for selecting different approaches, such as antibody humanization, isotype selection, lead candidate selection criteria and protein production. All contributors to this work are experts in their fields and many have played pivotal roles in the creation of these technologies.
Other form:	Print version: Antibody drug discovery. London : Imperial College Press, ©2012 9781848166288

Table of Contents:

Ch. 1. Humanization of antibodies / Olivier Leger and Jose W. Saldanha
ch. 2. Selection and screening of antibody phage display libraries / David R. Buckler [and others]
ch. 3. Affinity maturation approaches for antibody lead optimization / David Lowe, Trevor Wilkinson and Tristan J. Vaughan
ch. 4. Transgenic mice rearranging human antibodies / Sean Stevens
ch. 5. Isotype selection and Fc engineering: design and construction of fit-for-purpose therapeutic antibodies / William R. Strohl
ch. 6. Antibody expression from bacteria to transgenic animals / Paul Stephens and Berni M. Sweeney
ch. 7. Current trends in antibody purification and lead selection / Jie Chen and Andrew Nixon
ch. 8. Design and application of immunoconjugates for cancer therapy / Sherif El Sheikh [and others]
ch. 9. Dual-targeting bispecific antibodies as new therapeutic modalities for cancer / Zhenping Zhu
ch. 10. Antibody fragments and alternate protein scaffolds / Lioudmila Tchistiakova [and others].

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