Apoptosis methods in pharmacology and toxicology : approaches to measurement and quantification /

Apoptosis methods in pharmacology and toxicology : approaches to measurement and quantification /

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Bibliographic Details
Imprint:	Totowa, N.J. : Humana Press, ©2002.
Description:	1 online resource (xiv, 156 pages) : illustrations
Language:	English
Series:	Methods in pharmacology and toxicology, 1940-6053 Methods in pharmacology and toxicology.
Subject:	Apoptosis -- Research -- Methodology. Apoptosis -- physiology. Cytological Techniques. Apoptosis -- Research -- Methodology.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11154709

Hidden Bibliographic Details
Other authors / contributors:	Davis, Myrtle A.
ISBN:	9781592592791 1592592791 1280830646 9781280830648 9786610830640 6610830649 0896038904 9780896038905
Notes:	Includes bibliographical references and index. English. Print version record.
Summary:	Apoptosis, or programmed cell death, is a widespread cellular process that regulates numerous important biological events ranging from the metamorphosis of the tadpole tail to the elimination of surplus brain cells in the formation of proper synaptic connections. In Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification, Dr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful in toxicology and pharmacology research. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for quantifying and characterizing apoptosis, as well as protocols for the use of DNA microarray technology, high-throughput screens, and ELISA. Immunocytochemical methods for measuring biochemical and molecular endpoints in tissue sections will be highly useful for those carrying out studies in whole animal models as opposed to cell culture systems. Presented by authors well-versed in the technical problems and challenges in analyzing apoptosis, each method explicates its successful use, describes its limitations, and shows how it may be applied in large-scale screening operations. Concise and eminently practical, Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification offers pharmacologists, toxicologists, pathologists, and many other biomedical scientists today's gold standard reference source for methods that definitively identify and accurately quantify apoptosis.
Other form:	Print version: Apoptosis methods in pharmacology and toxicology. Totowa, N.J. : Humana Press, ©2002 0896038904
Standard no.:	10.1385/1592592791.

Description
Summary:	Dr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful for the design of toxicology and pharmacology studies. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for quantifying and characterizing apoptosis, as well as protocols for the use of DNA microarray technology, high throughput screens, and ELISA. Immunocytochemical methods for measuring biochemical and molecular endpoints in tissue sections will be highly useful for those carrying out studies in whole animal models as opposed to cell culture systems.
Physical Description:	1 online resource (xiv, 156 pages) : illustrations
Bibliography:	Includes bibliographical references and index.
ISBN:	9781592592791 1592592791 1280830646 9781280830648 9786610830640 6610830649 0896038904 9780896038905
ISSN:	1940-6053