Neuroinflammation in Neuronal Death and Repair /
Saved in:
| Imprint: | Amsterdam ; Boston : Elsevier Academic Press, 2007. |
|---|---|
| Description: | 1 online resource (xxiv, 474 pages, 26 unnumbered pages of plates) : illustrations (some color). |
| Language: | English |
| Series: | International review of neurobiology ; v. 82 International review of neurobiology ; v. 82. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11155746 |
Table of Contents:
- Cover
- Contents
- Contributors
- Preface
- Foreword
- Chapter 1: Inflammatory Mediators Leading to Protein Misfolding and Uncompetitive/Fast Off-Rate Drug Therapy for Neurodegenerative Disorders
- I. Introduction
- II. Protein Misfolding in Neurodegenerative Diseases
- III. Generation of RNS/ROS
- IV. Protein S-Nitrosylation and Neuronal Cell Death
- V. Parkin and the UPS
- VI. S-Nitrosylation and Parkin
- VII. The Unfolded Protein Response and PDI
- VIII. S-Nitrosylation of PDI Mediates Protein Misfolding and Neurotoxicity in Cell Models of PD or AD
- IX. PDI Activity in ALS and Prion Disease
- X. Potential Treatment of Excessive NMDA-Induced Ca2+ Influx and S-Nitrosylation
- XI. Looking to the Future: NitroMemantines
- XII. Conclusions
- Acknowledgments
- References
- Chapter 2: Innate Immunity and Protective Neuroinflammation: New Emphasis on the Role of Neuroimmune Regulatory Proteins
- I. Characteristics of the Cellular and Molecular Innate Immune Responses in the Brain
- II. Innate Immune Response in Health: The Key Role of Physical Barriers
- III. Immunoprivileged Status of the Brain by Preventing the Infiltration of Potentially Harmful Systemic Immune Cells: Roles of ACAMPs
- IV. Protective Innate Immune Response During Brain Infection and Inflammation to Promote the Clearance of Pathogens: Roles of PAMPs
- V. Interactions of Innate Immune Molecules with Toxic Proteins: Roles of PPAMPs
- VI. Regulating the Innate Immune Response in the CNS While Promoting Tissue Repair: Roles of Neuroimmune Regulatory Molecules
- VII. Innate Immunity and Neurogenesis
- VIII. The Canonical Innate Immune System in the CNS: The Complement System
- IX. Conclusion: Elements to Drive Innate Immune Neuroprotective Activities
- Glossary
- References
- Chapter 3: Glutamate Release from Astrocytes in Physiological Conditions and in Neurodegenerative Disorders Characterized by Neuroinflammation
- I. Introduction
- II. Ca2+-Dependent Glutamate Release from Astrocytes
- III. Excitotoxicity Involving Ca2+-Dependent Glutamate Release from Astrocytes in Pathological Conditions: The Case of ADC
- IV. Astrocytic Alterations and Ca2+-Dependent Glutamate Release Dysfunction in AD
- V. Conclusions
- References
- Chapter 4: The High-Mobility Group Box 1 Cytokine Induces Transporter-Mediated Release of Glutamate from Glial Subcellular Particles (Gliosomes) Prepared from in Situ-Matured Astrocytes
- I. Introduction
- II. Gliosomes as a Model to Study Astrocyte Characteristics
- A. Characterization of the Gliosome Preparation
- B. Glutamate Release in Gliosomes
- C. Expression of Proteins of the Release Machinery in Gliosomes
- III. HMGB1-Induced Glutamate Release from Gliosomes
- A. Cytokine Properties of HMGB1
- B. Effect of HMGB1 on Glutamate Release from Gliosomes and Synaptosomes
- C. Mechanisms of the HMGB1-Induced Release of Glutamate from Gliosomes
- D. HMGB1 Binding to Gliosomes
- IV. Concluding Remarks
- Acknowledgments
- References
- Chapter 5: The Role of Astrocytes and Complement System in Neural Plasticity
- I. Introduction
- II. Astrocytes, GFAP, and Astrocyte Intermediate Filaments
- III&#