Cardiovascular disease. methods and protocols / Volume 1, Genetics :

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Bibliographic Details
Imprint:Totowa, N.J. : Humana Press, ©2006.
Description:1 online resource (1 volume) : illustrations
Language:English
Series:Methods in molecular medicine ; 128
Methods in molecular medicine ; 128.
Subject:
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11157698
Hidden Bibliographic Details
Varying Form of Title:Genetics
Other authors / contributors:Wang, Qing K. (Qing Kenneth), 1965-
ISBN:9781597451598
1597451592
1588295729
9781588295729
1280832460
9781280832468
9786610832460
6610832463
Digital file characteristics:text file
PDF
Notes:Includes bibliographical references and index.
English.
Print version record.
Summary:Cardiovascular disease is the leading cause of death in developed countries, but is quickly becoming an epidemic in such well-populated countries as China, India, and other developing nations. Cardiovascular research is the key to the prevention, diagnosis, and management of cardiovascular disease. Vigorous and cross-disciplinary approaches are required for successful card- vascular research. As the boundaries between different scientific disciplines, particularly in the life sciences, are weakening and disappearing, a successful investigator needs to be competent in many different areas, including genetics, cell biology, biochemistry, physiology, and structural biology. The newly developed field of molecular medicine is a cross-disciplinary science that seeks to comprehend disease causes and mechanisms at the molecular level, and to apply this basic research to the prevention, diagnosis, and treatment of diseases and disorders. This volume in the Methods in Molecular Medicine series, C- diovascular Disease, provides comprehensive coverage of both basic and the most advanced approaches to the study and characterization of cardiovascular disease. These methods will advance knowledge of the mechanisms, diagnoses, and treatments of cardiovascular disease. Cardiovascular Disease is a timely volume in which the theory and pr- ciples of each method are described in the Introduction section, followed by a detailed description of the materials and equipment needed, and step-by-step protocols for successful execution of the method. A notes section provides advice for potential problems, any modifications, and alternative methods.
Other form:Print version: Cardiovascular disease. Volume 1, Genetics. Totowa, N.J. : Humana Press, ©2006 1588295729 9781588295729
Standard no.:10.1007/978-1-59745-159-8

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505 0 |a v. 1. Genetics: Cytogenetic analysis of cardiovascular disease: Karyotyping / M. Jarmuz [and others] -- Fluorescence in situ hybridization in cardiovascular disease / A.A. Timur [and others] -- Comparative genomic hybridization by microarray for the detection of cytogenetic imbalance / M. Jarmuz [and others] -- Construction of somatic cell hybrid lines: Fusion of mouse thymidine kinase-deficient 3T3 fibroblasts and human lymphoblastoid cells / A.A. Timur [and others] -- LINKAGE programs: Linkage analysis for monogenic cardiovascular diseases / L. Li [and others] -- SAGE programs: Model-free linkage analysis for complex cardiovascular phenotypes / S. Rao [and others] -- Linkage analysis for complex diseases using variance component analysis: SOLAR / U. Broeckel [and others] -- Genome resources and comparative analysis tools for cardiovascular research / G.E. Liu [and others] -- Positional cloning: Single-gene cardiovascular disorders / D. Li -- Positional cloning: Complex cardiovascular traits / J. Gulcher [and others] -- Chromosome substitution strains: A new way to study genetically complex traits / A.E. Hill [and others] -- Genome-wide association study to identify single-nucleotide polymorphisms conferring risk of myocardial infarction / K. Ozaki [and others] -- Mutation detection in congenital long qt syndrome: Cardiac channel gene screen using PCR, dHPLC, and direct DNA sequencing / D.J. Tester [and others] -- High-throughput single-nucleotide polymorphisms genotyping: TaqMan assay and pyrosequencing assay / G.Q. Shen [and others] -- Genotyping single-nucleotide polymorphisms by matrix-assisted laser desorption/ionization time-of-flight-based mini-sequencing / X. Sun [and others]. 
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520 |a Cardiovascular disease is the leading cause of death in developed countries, but is quickly becoming an epidemic in such well-populated countries as China, India, and other developing nations. Cardiovascular research is the key to the prevention, diagnosis, and management of cardiovascular disease. Vigorous and cross-disciplinary approaches are required for successful card- vascular research. As the boundaries between different scientific disciplines, particularly in the life sciences, are weakening and disappearing, a successful investigator needs to be competent in many different areas, including genetics, cell biology, biochemistry, physiology, and structural biology. The newly developed field of molecular medicine is a cross-disciplinary science that seeks to comprehend disease causes and mechanisms at the molecular level, and to apply this basic research to the prevention, diagnosis, and treatment of diseases and disorders. This volume in the Methods in Molecular Medicine series, C- diovascular Disease, provides comprehensive coverage of both basic and the most advanced approaches to the study and characterization of cardiovascular disease. These methods will advance knowledge of the mechanisms, diagnoses, and treatments of cardiovascular disease. Cardiovascular Disease is a timely volume in which the theory and pr- ciples of each method are described in the Introduction section, followed by a detailed description of the materials and equipment needed, and step-by-step protocols for successful execution of the method. A notes section provides advice for potential problems, any modifications, and alternative methods. 
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