TRP channels in drug discovery. Volume I /

TRP channels in drug discovery. Volume I /

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Bibliographic Details
Imprint:New York : Humana Press, ©2012.
Description:1 online resource (xi, 446 pages) : illustrations (some color)
Language:English
Series:Methods in pharmacology and toxicology, 1940-6053
Methods in pharmacology and toxicology.
Subject:
TRP channels.
Pharmacology.
Drug development.
Drug Discovery.
Transient Receptor Potential Channels.
Drug development.
Pharmacology.
TRP channels.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11159925
Hidden Bibliographic Details
Other authors / contributors:Szallasi, Arpad, 1958-
Bíró, Tamás.
ISBN:9781627030779
1627030778
162703076X
9781627030762
9781627030762
Digital file characteristics:text file PDF
Notes:Includes bibliographical references and index.
English.
Online resource; title from PDF title page (Springer Protocols, viewed Oct. 30, 2012).
Summary:Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention. TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field. Volume I presents a series of state-of-the-art minireviews on the most interesting TRP channels (from TRPA1 to TRPV4), as well as TRP-related protocols involving airways and the genitourinary tract. Written for the Methods in Pharmacology and ToxicologyTM series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab. Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.
Other form:Print version: TRP channels in drug discovery. v. 1. New York : Humana Press ; Springer, ©2012 9781627030762
Standard no.:10.1007/978-1-62703-077-9
Table of Contents:
  • Introduction to TRPs : a quest for novel drug targets / Bernd Nilius
  • TRP-mediated cytoskeletal reorganization : implications for disease and drug development / Chandan Goswami
  • TRPA1 in drug discovery / Jun Chen, Steve McGaraughty, and Philip R. Kym
  • Canonical transient receptor potential channel expression, regulation, and function in vascular and airway diseases / Brij B. Singh, Christina M. Pabelick, and Y.S. Prakash
  • TRPM2 function and potential as a drug target / Barbara A. Miller
  • Ca2+-activated monovalent cation-selective channels TRPM4 and TRPM5 / Barbara Colsoul, Miklos Kecskes, Koenraad Philippaert, Aurelie Menigoz, and Rudi Vennekens
  • Emerging role of TRPM7 in the regulation of magnesium homeostasis / Vladimir Chubanov, Jonathan T. Eggenschwiler, Lillia V. Ryazanova, Thomas Gudermann, and Alexey G. Ryazanov
  • TRPM8 channels as potential therapeutic targets for pain, analgesia, and thermoregulation / David D. McKemy
  • TRPML channels in function, disease, and prospective therapies / David A. Zeevi
  • TRPP signaling module : TRPP2/polycystin-1 and TRPP2/PKD1L1 / Alexis Hofherr
  • TRPV1 as a polymodal sensor : potential to discover TRPV1 antagonists selective for specific activating modalities / Olivier Radresa, Stephen Zicha, William Brown, and Jennifer M.A. Laird
  • Nociceptive and nonnociceptive roles of TRPV3 and its "druggability" / Sungjae Yoo and Sun Wook Hwang
  • TRPV4 and drug discovery / Fabien Vincent and Matthew A.J. Duncton
  • TRP expression and function in the lung airways / Alexander Dietrich and Thomas Gudermann
  • Hypoxia-dependent TRP channel function in pulmonary arterial smooth muscle cells / Beate Fuchs, Hermann Kalwa, Norbert Weissmann, Thomas Gudermann, and Alexander Dietrich
  • Endotoxin-induced airway inflammation and asthma models / Zsuzsanna Helyes and Zsófia Hajna
  • Enhanced cough, animal models / Raffaele Gatti, Pamela Pedretti, Romina Nassini, and Marcello Trevisani
  • Capsaicin inhalation test in man / Eva Millqvist
  • TRP channels in the genitourinary tract / Ana Charrua and Francisco Cruz
  • Animal models of cystitis / Célia D. Cruz and António Avelino
  • Overactive bladder models / Roberto Soler, Lysanne Campeau, Claudius Füllhase, and Karl-Erik Andersson.

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