Platelets in thrombotic and non-thrombotic disorders : pathophysiology, pharmacology and therapeutics /
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| Imprint: | Nambridge, U.K. ; New York : Nambridge University Press, 2002. |
|---|---|
| Description: | 1 online resource (xxii, 1101 pages, 16 unnumbered pages of plates) : illustrations (some color) |
| Language: | English |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11163628 |
Table of Contents:
- Prologue
- Part I. Physiology
- 1. History of platelets
- 2. Production of platelets
- 3. Morphology and ultrastructure of platelets
- 4. Platelet heterogeneity: physiology and pathological consequences
- 5. Platelet membrane proteins as adhesion receptors
- 6. Dynamics of the platelet cytoskeleton
- 7. Platelet organelles
- 8. Platelet receptors for thrombin
- 9. Platelet receptors: ADP
- 10. Platelet receptors: prostanoids
- 11. Platelet receptors: collagen
- 12. Platelet receptors: von Willebrand factor
- 13. Platelet receptor: fibrinogen
- 14. Platelet signalling: GTP-binding proteins
- 15. Platelet phospholipases A2
- 16. Roles of phospholipase C and phospholipase D in receptor-mediated platelet activation
- 17. Platelet signalling: calcium
- 18. Platelet signalling: protein kinase
- 19. Platelet signalling: tyrosine kinases
- 20. Platelet signalling: cAMP and cGMP
- 21. Platelet adhesion
- 22. The platelet shape change
- 23. Aggregation
- 24. Amplification loops: release reaction
- 25. Amplification loops: thromboxane generation
- 26. Platelet procoagulant activities: the amplification loops between platelets and the plasmatic clotting system
- 27. Platelets and chemotaxis
- 28. PlateletâÇôleukocyte interactions relevant to vascular damage and thrombosis
- 29. Vascular control of platelet function
- Part II. Methodology
- 30. In vitro assays for evaluating platelet functions
- 31. Monitoring antiplatelet therapy
- 32. Flow cytometric analysis of platelets function
- 33. Animal models of platelet-dependent thrombosis
- Part III. Pathology
- A. Hemostasis
- 34. Hereditary thrombocytopenias
- 35. Thrombocytopenias due to bone marrow disorders
- 36. Immune mediated thrombocytopenia
- 37. Thrombocytopenia in childhood
- 38. Alloimmune thrombocytopenia
- 39. Drug-induced and drug-dependent immune thrombocytopenias
- 40. Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
- 41. Thrombocytosis and thrombocythemia
- 42. Platelet adhesive protein defect disorders
- 43. Congenital disorders of platelet secretion
- 44. Congenital platelet signal transduction defects
- 45. Acquired platelet function defects
- 46. Platelet storage and transfusion
- B. Thrombosis
- 47. Phatophysiology of arterial thrombosis
- 48. Platelets and atherosclerosis
- 49. Platelet involvement in venous thrombosis and pulmonary embolism
- 50. Gene regulation of platelet function
- C. Non-hemostatic disorders
- 51. Platelets and bacterial infections
- 52. Interactions of viruses and platelets and the inactivation of viruses in platelet concentrates prepared for transfusion
- 53. Platelets and parasites
- 54. Platelets and tumours
- 55. Platelets and renal diseases
- 56. Platelets and allergic diseases
- 57. Platelet interactions with other cells related to inflammatory diseases
- 58. Platelets and the preimplantation stage of embryo development
- 59. Platelet in psychiatric and neurological disorders
- 60. Platelets in inflammatory bowel disease
- Part IV. Pharmacology
- 61. Aspirin
- 62. Pharmacology of ticlopidine clopidogrel
- 63. Platelet membrane glycoprotein (GP) IIb1âÇôIIIa antagonists and acute arterial thrombosis
- 64. Other antiplatelet agents
- 65. Pharmacogenetics as a new antiplatelet strategy
- 66. Cardiovascular gene therapy: implications for platelet vessel wall interactions
- 67. Pharmacological modulation of the inflammatory actions of platelets
- Part V. Therapy
- 68. Design of trials to evaluate antiplatelet agents
- 69. Antiplatelet therapy in cardiology
- 70. Antiplatelet therapies in neurology
- 71. Antiplatelet treatment in peripheral vascular disease