Meselson, Stahl, and the replication of DNA : a history of "the most beautiful experiment in biology" /

Meselson, Stahl, and the replication of DNA : a history of "the most beautiful experiment in biology" /

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Bibliographic Details
Author / Creator:	Holmes, Frederic Lawrence.
Imprint:	New Haven, CT : Yale University Press, 2001.
Description:	1 online resource (xii, 503 pages) : illustrations
Language:	English
Subject:	Meselson, Matthew. Stahl, Franklin W. Meselson, Matthew. Stahl, Franklin W. DNA replication -- Experiments -- History. Molecular biology -- Experiments -- History. DNA Replication. Molecular Biology -- history. Molecular biology -- Experiments. History. Electronic books.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11164597

Hidden Bibliographic Details
ISBN:	9780300129663 0300129661 1281730459 9781281730459 9780300085402 0300085400
Digital file characteristics:	data file
Notes:	Includes bibliographical references (pages 449-496) and index. Print version record.
Summary:	In 1957 Matthew Meselson and Frank Stahl produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a 'most beautiful' experiment whose beauty was tied to its simplicity. This book vividly reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research - its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty.
Other form:	Print version: Holmes, Frederic Lawrence. Meselson, Stahl, and the replication of DNA. New Haven, CT : Yale University Press, 2001

Table of Contents:

Contents
Preface
Acknowledgments
Introduction
The Replication Problem
Meselson and Stahl
Twists and Turns
Crossing Fields: Chemical Bonds to Biological Mutants
Dense Solutions
The Big Machine
Working at High Speed
The Unseen Band
One Discovery, Three Stories
An Extremely Beautiful Experiment
Centrifugal Forces
The Subunits of Semiconservative Replication
Images of an Experiment
Afterword
Abbreviations Used in Notes
Notes
Index