Hepatitis B virus : molecular mechanisms in disease and novel strategies for therapy /

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Bibliographic Details
Imprint:	London : Imperial College Press ; River Edge, NJ : World Scientific [distributor], 1998.
Description:	1 online resource (viii, 328 pages) : illustrations
Language:	English
Subject:	Hepatitis B virus. Hepatitis B. Hepatitis B. Hepatitis B virus. Hepatitis B virus. Electronic books.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11170206

Hidden Bibliographic Details
Other authors / contributors:	Koshy, Rajen. Caselmann, Wolfgang H.
ISBN:	9781848161078 1848161077 1860940072 9781860940071
Notes:	Includes bibliographical references and indexes. Print version record.
Summary:	The book covers both the molecular aspects of hepatitis B virus replication and gene expression in vivo and in model systems, and the clinical impact of genetic variants or immunological response in chronic infection. Major emphasis is laid on the molecular mechanisms underlying hepatitis B virus-associated liver carcinogenesis and their possible relevance to therapy and to the prevention of infection. Rational approaches to design novel vaccines or cytokine treatments, as well as strategies to develop vectors for liver-directed gene therapy, are discussed.
Other form:	Print version: Hepatitis B virus. London : Imperial College Press ; River Edge, NJ : World Scientific [distributor], 1998 1860940072

Table of Contents:

pt. 1. Molecular biology of Hepatitis B virus
Replication of the Hepatitis B virus genome / Christoph Seeger
The regulation of Hepatitis B virus gene expression: an overview of the cis- and trans- acting components / Marshall J. Kosovsky
Animal models and experimental systems in Hepatitis B virus research / Stepahn Schaefer
pt. 2. Infection and chronic disease
Natural course of HBV infection / Hubert E. Blum
Genetic variants of HBV / Tim J. Harrison
The immunology of chronic hepatitis B / Barbara Rehermann
pt. 3. Hepatocellular carcinoma
HBV DNA integration and insertional mutagenesis / Katsuro Koike
Transactivators of HBV, signal transduction and tumorigenesis / Wolfgang H. Caselmann
Oncogenes, tumour suppressors and co-factors in hepatocellular carcinoma / Hisaki Nagai
pt. 4. Rational approaches for the prevention of infection and therapy
Hepatitis B virus vaccines / Florian Schödel
Chronic hepatitis B viral infection: cytokines and therapy / Graham R. Foster
The development of targettable vectors for the liver and prospects for treatment / Ludwig Weiss.

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