Penicillin : biosynthesis, applications and adverse effects /
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| Imprint: | New York : Nova Science Publishers, ©2012. |
|---|---|
| Description: | 1 online resource (xi, 158 pages) : illustrations. |
| Language: | English |
| Series: | Pharmacology - research, safety testing and regulation Pharmacology-research, safety testing, and regulation series. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11179713 |
Table of Contents:
- PENICILLINBIOSYNTHESIS, APPLICATIONS AND ADVERSE EFFECTS; PHARMACOLOGY
- RESEARCH, SAFETY TESTING AND REGULATION; PENICILLINBIOSYNTHESIS, APPLICATIONS AND ADVERSE EFFECTS; LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA; CONTENTS; PREFACE; CHAPTER 1. MOLECULAR MODIFICATION OF BIOSYNTHETIC GENES FOR IMPROVED PRODUCTION OF PENICILLINS AND CEPHALOSPORINS; ABSTRACT; INTRODUCTION; BIOSYNTHESIS OF b-LACTAM ANTIBIOTICS; Biosynthesis of Penicillin; Biosynthesis of Cephalosporin C; Biosynthesis of Cephamycin C; Biosynthesis of Cephabacin; DEVELOPMENT OF SEMI-SYNTHETIC PENICILLINS.
- GENETIC MANIPULATION OF b-LACTAM PRODUCERS TO IMPROVE PENICILLIN PRODUCTION YIELDPenicillin Production Improved by Classical Strain-Improvement; Application of Molecular Biology Techniques for Improved Penicillin Production; DEVELOPMENT OF SEMI-SYNTHETIC CEPHALOSPORINS; INDUSTRIAL SYNTHESIS OF CEPHALOSPORIN PRECURSORS; GENETIC MANIPULATION OF (SB (B-LACTAM PRODUCERS TO IMPROVE CEPHALOSPORIN PRODUCTION; KEY ENZYMES IN b-LACTAM BIOSYNTHESIS; Isopenicillin N Synthase (IPNS); Deacetoxycephalosporin C Synthase (DAOCS); DAOCS: a Fe(II) and 2-Oxoglutarate Dependent Dioxygenase.
- Biochemical Characterization of DAOCSStructural and Mechanistic Studies of DAOCS; Modification of DAOCS to Improve its Substrate Bindingand Catalytic Activity; Recombinant DAOCSs; Rational Engineering of DAOCS; FUTURE DEVELOPMENT OF b-LACTAM ANTIBIOTICS; REFERENCES; CHAPTER 2. DEVELOPMENTS IN THE SEPARATION AND RECOVERY OF PENICILLIN G USING HOLLOW-FIBER MEMBRANE CONTACTORS; ABSTRACT; NOTATION; Subscripts; Superscripts; Greek Symbols; INTRODUCTION; MECHANISM AND KINETICS OF REACTIVE EXTRACTION; PHYSICAL AND REACTIVE EXTRACTIONSOF PENICILLIN G; Equilibrium Experiments.
- HOLLOW FIBER MEMBRANE MODULEHollow-Fiber Experiments: Effect of Solvent Type; EXTRACTIONS WITH SUNFLOWER OIL; RE-EXTRACTION (RECOVERY) OF PENICILLIN G FROM THE ORGANIC PHASE; MATHEMATICAL MODELLING OF MASS TRANSFER IN HOLLOW-FIBRE MODULE; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 3. NOVEL PEPTIDE ENDOWED WITH ANTIBIOTIC PROPERTIES; ABSTRACT; INTRODUCTION; FROM THE ENZYME TO THE ABZYMEAND ITS SCFV COUNTERPART; THE PHAGE DISPLAY TECHNOLOGY: A POWERFUL TOOL TO SELECT ACTIVE BIOMOLECULES.