Mental retardation and developmental delay : genetic and epigenetic factors /

Mental retardation and developmental delay : genetic and epigenetic factors /

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Bibliographic Details
Author / Creator:	Smith, Moyra.
Imprint:	Oxford : Oxford University Press, ©2006.
Description:	1 online resource (xix, 317 pages) : illustrations
Language:	English
Series:	Oxford Monographs on Medical Genetics Oxford monographs on medical genetics.
Subject:	Intellectual disability -- Etiology. Intellectual disability -- Genetic aspects. Developmental disabilities -- Etiology. Developmental disabilities -- Genetic aspects. Intellectual Disability -- genetics. Child. Infant. Developmental Disabilities -- etiology. Developmental Disabilities -- genetics. Intellectual Disability -- etiology. Developmental disabilities -- Etiology. Developmental disabilities -- Genetic aspects. Intellectual disability -- Etiology. Intellectual disability -- Genetic aspects. Electronic books.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11198880

Hidden Bibliographic Details
ISBN:	9780198038856 0198038852 9786610843916 6610843910 9780195174328 0195174321 1280843918 9781280843914 0195174321
Notes:	Includes bibliographical references and index. Print version record.
Summary:	Introduction. 1. Science, Society, and Mental Retardation, A History. 2. Neurogenesis, Neuronal Migration, Maturation, and Function: Insights into Learning and Memory. 3. Structural Brain Anomalies and Neural Tube Defects. 4. Mental Retardation Associated with Dysmorphology, Growth Retardation, or Overgrowth. 5. Mental Retardation Associated with Other Neurological Defects. 6. Mental Retardation that Develops After a Period of Norma Cognition. 7. Nonsyndromic Mental Retardation, Autism, and Language Deficits. 8. Genomics, Functional Genomics, and Epigenetics: Relevance to Mental Retardation. 9.
Other form:	Print version: Smith, Moyra. Mental retardation and developmental delay. Oxford : Oxford University Press, ©2006

Description
Summary:	Recent advances in neuroscience and genetics have greatly expanded our understanding of the brain and of the etiological factors involved in developmental delay and mental retardation. At the same time, the human genome project has yielded a wealth of information on DNA sequencing, regulation of gene expression, epigenetics, and functional aspects of the genome, which newly propels investigation into the pathogenesis of mental retardation. This book makes readily available current knowledge on the subject and applies it to clinical medicine, providing information essential to neurologists, geneticists, physicians and pediatricians as they search for the causes of mental handicap in their patients. Introductory chapters cover normal and abnormal brain structure, neurogenesis, neuronal proliferation, and signal transduction. Latter chapters delve into discussions of both the environmental factors that may lead to neurocognitive deficits and the cytogenetic, biochemical and molecular defects specifically associated with mental retardation. One chapter reviews gene involvement in non-syndromic mental retardation, autism, and language deficits, as well as multifactorial and genetically complex inheritance. The text concludes with a clinically practical discussion of carrier detection, presymptomatic diagnosis, and treatment of various genetic diseases through enzyme therapy, substrate deprivation, and the use of hemapoietic stem cells.
Physical Description:	1 online resource (xix, 317 pages) : illustrations
Bibliography:	Includes bibliographical references and index.
ISBN:	9780198038856 0198038852 9786610843916 6610843910 9780195174328 0195174321 1280843918 9781280843914