Phosphatase modulators /

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Bibliographic Details
Imprint:	New York : Humana Press, [2013] ©2013
Description:	1 online resource (x, 315 pages) : illustrations (some color)
Language:	English
Series:	Methods in molecular biology, 1940-6029 ; volume no. 1053 Methods in molecular biology (Clifton, N.J.) ; v. 1053.
Subject:	Phosphatases. Phosphoprotein phosphatases. Drugs -- Design. Esterases. Hydrolases. Enzymes. Publication Formats Esterases Hydrolases Publication Characteristics Enzymes Enzymes and Coenzymes Chemicals and Drugs Laboratory Manuals Phosphoric Monoester Hydrolases Phosphoprotein Phosphatases Drug Design Hydrolases Esterases Enzymes Drugs -- Design Phosphatases Phosphoprotein phosphatases Laboratory Manual Laboratory manuals.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11200452

Hidden Bibliographic Details
Other authors / contributors:	Millán, José Luis, editor.
ISBN:	9781627035620 1627035621 9781627035613 1627035613
Digital file characteristics:	text file PDF
Notes:	Includes bibliographical references and index. English. Online resource; title from PDF title page (Springer, viewed July 17, 2013).
Summary:	Driving further the research on mammalian alkaline phosphatase structure and function, Phosphatase Modulators collects expert contributions into one "how to" manual for basic scientists interested in initiating a drug discovery effort. While this book contains the traditional method chapters and some typical reviews on the structure and known functions of phosphatases, other contributions are meant to discuss approaches and alternatives useful in making "go/no-go" decisions in high throughput screening (HTS) and lead optimization campaigns. Many chapters focus on tissue-nonspecific alkaline phosphatase (TNAP) as well as protein phosphatases. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detail and key implementation advice that promotes reproducible results. Step-by-step and practical, Phosphatase Modulators offers a path to understanding many of the facets and complexities associated with undertaking a drug discovery effort and will serve as a roadmap to initiating those efforts
Other form:	Print version: Phosphatase modulators. New York : Humana Press ; Springer, ©2013 1627035613
Standard no.:	10.1007/978-1-62703-562-0

Table of Contents:

Chemical Probe Development Versus Drug Development
Phosphatase High-Throughput Screening Assay Design and Selection
Multisystemic Functions of Alkaline Phosphatases
Robotic Implementation of Assays: Tissue-Nonspecific Alkaline Phosphatase (TNAP) Case Study
Robotic Implementation of Assays: Tissue-Nonspecific Alkaline Phosphatase (TNAP) Case Study
A Method for Direct Assessment of Tissue-Nonspecific Alkaline Phosphatase (TNAP) Inhibitors in Blood Samples
Isolation and Characteristics of Matrix Vesicles
The Use of Tissue-Nonspecific Alkaline Phosphatase (TNAP) and PHOSPHO1 Inhibitors to Affect Mineralization by Cultured Cells
Modulators of Intestinal Alkaline Phosphatase
New Activity Assays for ENPP1 with Physiological Substrates ATP and ADP
Structure of Acid Phosphatases
Purification of Prostatic Acid Phosphatase (PAP) for Structural and Functional Studies
Protein Tyrosine Phosphatases: Structure, Function, and Implication in Human Disease
High-Throughput Screening for Protein Tyrosine Phosphatase Activity Modulators
Evaluating Effects of Tyrosine Phosphatase Inhibitors on T Cell Receptor Signaling
Interactor-Guided Dephosphorylation by Protein Phosphatase-1
Structure, Regulation, and Pharmacological Modulation of PP2A Phosphatases.

Phosphatase modulators /

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