| Summary: | This volume on the application of bioinformatics to sequence analyses is divided in three sections.
Section I deals with data and databases.
Includes chapters on a selection of methods involving the generation and organization of data, including sequence data, RNA and protein structures, microarray expression data, and functional annotations.
Section II presents a selection of methods in sequence analysis, beginning with multiple sequence alignment.
Most of the chapters in this section deal with methods for discovering the functional components of genomes, whether genes, alternative splice sites, non-coding RNAs, or regulatory motifs.
Section III presents several of the most useful and interesting methods in phylogenetics and evolution.
The wide variety of topics treated in this section is indicative of the breadth of evolution research.
Includes chapters on some of the most basic issues in phylogenetics: modelling of evolution and inferring trees.
It also includes chapters on drawing inferences about various kinds of ancestral states, systems, and events, including gene order, recombination events and genome rearrangements, ancestral interaction networks, lateral gene transfers, and patterns of migration.
It concludes with a chapter discussing some of the achievements and challenges of algorithm development in phylogenetics.
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