Structural virology /

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Bibliographic Details
Imprint:	Cambridge : Royal Society of Chemistry, [2010], ©2011.
Description:	1 online resource (299 pages)
Language:	English
Series:	RSC Biomolecular Sciences ; 21 RSC biomolecular sciences ; 21.
Subject:	Viruses -- Morphology. Molecular virology. Organisms Viral Structural Proteins. Microbiological Phenomena. Phenomena and Processes Viral Proteins. Proteins. Amino Acids, Peptides, and Proteins Chemicals and Drugs Nucleocapsid Proteins. Viruses. Virus Physiological Phenomena. Molecular virology. Viruses -- Morphology.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11215726

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Other authors / contributors:	Agbandje-McKenna, Mavis.
ISBN:	9781849732239 184973223X
Notes:	Online resource; title from title screen (viewed on June 15, 2010).
Summary:	Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscop.
Standard no.:	10.1039/9781849732239

Table of Contents:

Introduction: Principles of Virus Structure
Section 1. Methodologies for Structural Analysis of Viruses
Production and Purification of Viruses for Structural Studies
Microscopic (Confocal) Analysis of Viral Entry and Infection
Cryo-electron Microscopy of Virus Infection - Tomography and Asymmetric Structure Determination
Cryo-electron Microscopy of Viruses - 3D of Virus Capsids
X-ray Crystallography of Virus Capsids
Structural Studies of Viral Proteins
Probing Viral Capsid Structures in Solution
Section 2. Structure to Function Correlation for Viruses
Evolution of Viral Capsid Structures - the Three Domains of Life
Mechanisms of Virus Capsid Assembly
Mechanisms of Genome Packaging
Attachment and Viral entry - Receptor Recognition in Viral Pathogenesis
Attachment and Entry - Viral Cell Fusion
Virus Antibody Recognition
Section 3. Therapeutic Strategies Based on Viral Structures
Development of anti-HIV drugs
Design of Influenza Vaccines and Antiviral Agents Engineering Viral Capsids as Nano Tools
Viral Vectors for Gene Delivery

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