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|a Sex Differences and Implications for Translational Neuroscience Research :
|b Workshop Summary /
|c Diana E. Pankevich, Theresa Wizemann, and Bruce M. Altevogt, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine of the National Academies.
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| 260 |
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|a Washington, DC :
|b National Academies Press,
|c ©2011.
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|a Includes bibliographical references.
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|a Biologically based differences between the sexes impact human development and behavior in both obvious and subtle ways. Sex differences are also apparent across the spectrum of health and disease, impacting not only individual health, but also public health, biomedical research, and healthcare delivery. Researchers have begun to elucidate these differences and their potential impact in areas such as pain and pain perception, infection, longevity, disease incidence and course, and cellular response and inflammation. Studies have shown, for example, that males and females can have markedly different responses to certain medications; in some cases these unexpected differences have led to the recall of products from the market (GAO, 2001). In the current era of translational research and personalized medicine, it is increasingly important to take sex differences into account, so that the potential effects of products and therapies can be more fully understood.
|
| 536 |
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|a This project was supported by contracts between the National Academy of Sciences and the Alzheimer's Association; AstraZeneca Pharmaceuticals, Inc.; CeNeRx Biopharma; the Department of Health and Human Services' National Institutes of Health (NIH, Contract Nos. N01-OD-4-213) through the National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, National Eye Institute, NIH Blueprint for Neuroscience Research, National Institute of Mental Health, and National Institute of Neurological Disorders and Stroke; Eli Lilly and Company; GE Healthcare, Inc.; GlaxoSmithKline, Inc.; Johnson & Johnson Pharmaceutical Research and Development, LLC; Merck Research Laboratories; the National Multiple Sclerosis Society; the National Science Foundation (Contract No. OIA-0753701); the Society for Neuroscience; and Wyeth Research, Inc.
|
| 505 |
0 |
0 |
|t Introduction --
|t Studying sex difference in health and disease --
|t Studying sex differences in translational research: examples from four major disease areas --
|t Reporting sex differences in research publications --
|t Sex differences in drug development: policy and practice --
|t Needs, opportunities, and next steps.
|
| 546 |
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|a English.
|
| 650 |
|
0 |
|a Sex factors in disease
|x Research.
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| 650 |
|
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|a Sex differences
|x Research.
|
| 650 |
|
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|a Health
|x Sex differences
|x Research.
|
| 650 |
|
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|a Human biology
|x Sex differences.
|
| 650 |
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|a Neurosciences
|x Research.
|
| 650 |
1 |
2 |
|a Translational Medical Research.
|0 https://id.nlm.nih.gov/mesh/D057170
|
| 650 |
2 |
2 |
|a Neurosciences
|x methods.
|0 https://id.nlm.nih.gov/mesh/D009488Q000379
|
| 650 |
2 |
2 |
|a Sex Factors.
|0 https://id.nlm.nih.gov/mesh/D012737
|
| 650 |
|
7 |
|a MEDICAL
|x Physiology.
|2 bisacsh
|
| 650 |
|
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|a SCIENCE
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| 650 |
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|a Sex differences
|x Research.
|2 fast
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| 655 |
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0 |
|a Electronic books.
|
| 655 |
|
2 |
|a Congress.
|0 https://id.nlm.nih.gov/mesh/D016423
|
| 655 |
|
4 |
|a Electronic books.
|
| 700 |
1 |
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|a Pankevich, Diana E.,
|d 1975-
|0 http://id.loc.gov/authorities/names/no2011014350
|
| 700 |
1 |
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|a Wizemann, Theresa M.
|
| 700 |
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|a Altevogt, Bruce M.
|0 http://id.loc.gov/authorities/names/n2006181643
|
| 710 |
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|a Institute of Medicine (U.S.).
|b Forum on Neuroscience and Nervous System Disorders.
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| 776 |
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|d Washington : National Academies Press, 2010
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