Immunotherapy of Cancer /
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| Imprint: | Waltham, MA : Academic Press, 2015. |
|---|---|
| Description: | 1 online resource (xv, 375 pages, 14 unnumbered pages of plates : illustrations (some color)). |
| Language: | English |
| Series: | Advances in cancer research ; volume 128 Advances in cancer research ; v. 128. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11247104 |
Table of Contents:
- Contributors
- Preface
- 1. The New Era of Cancer Immunotherapy: Manipulating T-Cell Activity to Overcome Malignancy
- 1. Introduction
- 2. Modulation of T-Cell Activity with mAbs
- 3. Adoptive T-Cell Transfer
- 4. Small Molecules for Immune Modulation
- 5. Other Approaches
- 6. Conclusion
- Acknowledgments
- References
- 2. Immune Targeting of Tumor Epithelial-Mesenchymal Transition via Brachyury-Based Vaccines
- 1. Introduction
- 2. Tumor EMT
- 3. Targeting of EMT
- 4. Overcoming Potential Tumor Immune Resistance
- 5. Concluding Remarks
- Acknowledgments
- References
- 3. Myeloid-Derived Suppressor Cells: Critical Cells Driving Immune Suppression in the Tumor Microenvironment
- 1. Myeloid-Derived Suppressor Cell History
- 2. MDSC Development and Suppressive Functions Are Induced by Inflammation
- 3. MDSC Are Regulated by Multiple Molecular Mechanisms
- 4. MDSCs Utilize a Network of Effector and Signaling Molecules to Modulate the Inflammatory Milieu and Decrease Immune Surveillance
- 5. MDSCs in Noncancer Settings
- 6. Therapeutic Targeting of MDSCs
- 7. Conclusions
- References
- 4. Phagocytes as Corrupted Policemen in Cancer-Related Inflammation
- 1. Introduction
- 2. Origin and Functions of TAMs
- 3. Macrophages in Complement-Mediated, PTX3-Regulated Tumor Promotion
- 4. The Yin Yang of TAMs in Anticancer Therapy
- 5. Neutrophils and Cancer
- 6. Concluding Remarks
- Acknowledgment
- References
- 5. Tumor-Elicited Inflammation and Colorectal Cancer
- 1. Introduction
- 2. Cytokines in CRC Development
- 3. Commensal Flora, Barrier Defect, and Tumor-Elicited Inflammation
- 4. Conceding Remarks and Therapeutic Outiook
- References
- 6. Therapeutic Lymphoid Organogenesis in the Tumor Microenvironment
- 1. Introduction
- 2. Development of TLSs in Chronically Diseased Tissues
- 3. TLSs in Cancer; Clinical Correlates of Disease Progression and Response to Treatment
- 4. Cues for TLS Development
- 5. Therapeutic Manipulation of TLSs in Cancer patients: Establishing a Paradigm for Antitumor Efficacy
- 6. Importance of IL-1 Family Member Cytokines in Establishing Therapeutic TLSs
- 7. Conclusions and Future Directions for Clinical Translation
- Acknowledgment
- References
- 7. The Tumor Macroenvironment: Cancer-Promoting Networks Beyond Tumor Beds
- 1. Introduction
- 2. Interactions Between the TME and the Bone Marrow
- 3. Subsets of Myeloid Precursors Pathologically Mobilized in Tumor-Bearing Hosts
- 4. Lineage-Committed Myeloid Populations in the TME
- 5. Metastatic Spreading and the Metastatic Niche
- 6. Role of the Microbiota in Tumor Progression
- 7. Distally Produced Hormones Influence Tumor Progression
- 8. Conclusions
- Acknowledgments
- References
- 8. Control of CD8 T-Cell Infiltration into Tumors by Vasculature and Microenvironment
- 1. Prognostic Significance of Immune Cell Representation in Tumors
- 2. CD8 T-Cell Representation in Tumors as a Predictive Marker of Responsiveness to Therapy
- 3. Determinants of CD8 T-Cell Representation in Tumors and Other Tissues
- 4. Tumors Develop HEV-Like Vasculature
- 5. Altering the Tumor Vasculature to Support Enhanced Entry of Naive and Effector T-Cells
- References
- 9. Scavenger Receptors: Emerging Roles in Cancer Biology and Immunology
- 1. Introduction
- 2. Scavenger Receptors in Cancer Immunobiology
- 3. Scavenger Receptors in Cancel Therapy
- 4. Concluding Remarks
- Acknowledgments
- References
- Index