Designer receptors exclusively activated by designer drugs /

Saved in:

Bibliographic Details
Imprint:	New York, NY : Humana Press, 2015.
Description:	1 online resource (xvii, 160 pages) : illustrations (some color)
Language:	English
Series:	Neuromethods, 0893-2336 ; 108 Neuromethods ; 108.
Subject:	G proteins -- Receptors -- Laboratory manuals. Designer drugs -- Laboratory manuals. Designer Drugs. GTP-Binding Proteins. Designer drugs. G proteins -- Receptors. Laboratory manuals. Electronic books.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11248180

Hidden Bibliographic Details
Other authors / contributors:	Thiel, Gerald, editor.
ISBN:	9781493929443 1493929445 1493929437 9781493929436 9781493929436
Notes:	Includes bibliographical references and index. Online resource; title from PDF title page (SpringerLink, viewed September 14, 2015).
Summary:	Providing current methods to analyze the properties of designer receptors exclusively activated by designer drugs (DREADDs) in vitro and to measure the biological responses of DREADD activation in different neuronal populations in vivo, chapters focus on the utility of DREADD technology to selectively stimulate or inhibit neuronal activity in selected brain areas of transgenic mice. In addition, the successful use of DREADD expression in rats and Drosophila is described. Together, the DREADD technology represents a non-invasive, chemical-genetic tool for investigating neuronal signaling and the resulting behavioural responses in vivo.
Other form:	Print version: Designer receptors exclusively activated by designer drugs. New York, NY : Humana Press, 2015
Standard no.:	10.1007/978-1-4939-2944-3 9781493929436

Table of Contents:

Defining the Functional Equivalence of Wild Type and Chemically Engineered G Protein-Coupled Receptors
Design and Analysis of an Arrestin-biased DREADD
Regulation of Gene Transcription Following Stimulation of Gaq-coupled Designer Receptors
Chemogenetic Deconstruction of Feeding Circuits
Dissecting Neuronal Circuits Involved in Olfactory Mediated Behaviors
The use of DREADDs (Designer Receptors Exclusively Activated by Designer Receptors) in Transgenic Mouse Behavioral Models
Pharmacogenetic Dissection of Neural Mechanisms Underlying the Regulation of Sleep/Wakefulness using DREADDs
DREADD'ed addiction: Using Designer Receptors to Delineate Neural Circuits Underlying Drug-Seeking Behaviors
DREADDs in Drosophila melanogaster.

Similar Items