Organic cation transporters : integration of physiology, pathology, and pharmacology /

Organic cation transporters : integration of physiology, pathology, and pharmacology /

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Bibliographic Details
Imprint:Cham : Springer, [2016]
©2016
Description:1 online resource (xv, 264 pages) : illustrations (some color)
Language:English
Subject:
Carrier proteins.
Cations.
Membrane Transport Proteins -- physiology.
Biological Transport -- physiology.
Carrier proteins.
Cations.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11251579
Hidden Bibliographic Details
Other authors / contributors:Ciarimboli, Giuliano, 1962- editor.
Gautron, Sophie, editor.
Schlatter, Eberhard, editor.
ISBN:9783319237930
3319237934
3319237926
9783319237923
9783319237923
Digital file characteristics:text file
PDF
Notes:Includes index.
Includes bibliographical references and index.
English.
Online resource; title from PDF title page (SpringerLink, viewed December 28, 2015).
Summary:This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.
Other form:Printed edition: 9783319237923
Standard no.:10.1007/978-3-319-23793-0
Table of Contents:
  • Introduction to the cellular transport of organic cations
  • Functional properties of organic cation transporter OCT1, binding of substrates and inhibitors, and presumed transport mechanism
  • Pharmacological and toxicological significance of the organic cation transporters OCT and MATE: Drug disposition, interaction and toxicity
  • Genetic variability in organic cation transporters: pathophysiological manifestations and consequences for drug pharmacokinetics and efficacy
  • Physiological and pathological regulation of transporters for organic cations
  • Endocrine and metabolic regulation of transporters for organic cations
  • Organic cation transporters (OCTs) as modulators of behavior and mood
  • Organic cation transporters as modulators of neurodegeneration and neuroprotection
  • Translational relevance of animal models for the study of organic cation transporter function
  • Role of transporters for organic cations in plants for environmental cycling of pharmaceutical residues.

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