Genome editing : the next step in gene therapy /

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Bibliographic Details
Imprint:	New York, NY : Springer, 2016.
Description:	1 online resource (xvi, 263 pages) : illustrations (some color)
Language:	English
Series:	Advances in experimental medicine and biology, 0065-2598 ; volume 895 Advances in experimental medicine and biology ; v. 895.
Subject:	Genetic engineering. Gene therapy. Bioengineering. Genetic Therapy. Gene therapy. Genetic engineering. Electronic books.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11253408

Hidden Bibliographic Details
Other authors / contributors:	Cathomen, Toni, editor. Hirsch, Matthew, editor. Porteus, Matthew H., editor.
ISBN:	9781493935093 1493935097 1493935070 9781493935079 9781493935086 1493935089 9781493980611 1493980610 9781493935079
Digital file characteristics:	text file PDF
Notes:	Includes index. English. Online resource; title from PDF title page (SpringerLink, viewed March 7, 2016).
Summary:	This comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genome editing for neuromuscular diseases, phase integrases, triplex forming oligonucleotides and peptide nucleic acids, aptamer-guided gene targeting, AAV gene editing via DSB repair, engineered nucleases and trinucleotide repeat diseases, and creation of HIV-resistant cells. The expertly authored chapters contextualize current developments within the history of genome editing while also discussing the current and potential safety concerns of this rapidly growing field. Genome Editing: The Next Step in Gene Therapy, the latest volume in the American Society of Gene and Cell Therapy series, deftly illuminates the potential of genetic engineering technology to eradicate today's deadliest and most prolific diseases. It is ideal reading for clinicians and researchers in genetics and immunology.
Other form:	Printed edition: 9781493935079
Standard no.:	10.1007/978-1-4939-3509-3

Table of Contents:

1. Gene Editing: Double-Strand Break Induced Gene Targeting and Mutagenesis 20 Years Later
2. The Development and Use of Zinc-Finger Nucleases
3. The Use and Development of TAL Effector Nucleases
4. Genome Editing for Neuromuscular Diseases
5. Phage Integrases for Genome Editing
6. Precise Genome Modification Using Triplex Forming Oligonucleotides and Peptide Nucleic Acids
7. Genome Editing by Aptamer-Guided Gene Targeting
8. Stimulation of AAV Gene Editing via DSB Repair
9. Engineered Nucleases and Trinucleotide Repeat Diseases
10. Using Engineered Nucleases to Create HIV-Resistant Cells
11. Strategies to Determine Off-Target Effects of Engineered Nucleases.

Genome editing : the next step in gene therapy /

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