The genetics of type 2 diabetes and related traits : biology, physiology and translation /

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Bibliographic Details
Imprint:Switzerland : Springer, [2016]
©2016
Description:1 online resource
Language:English
Subject:
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11254723
Hidden Bibliographic Details
Other authors / contributors:Florez, Jose C., editor.
ISBN:9783319015743
3319015745
3319015737
9783319015736
9783319015736
Notes:Includes bibliographical references and index.
Online resource; title from PDF title page (EBSCO, viewed April 19, 2016).
Summary:This book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes. The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and the arrival of next-generation sequencing. A further section goes beyond genetics to illustrate how other data sources can help interpret genetic data, such as leveraging population diversity, the correlation of genetic associations with physiological measurements, gene expression modulation, environmental factors and our microbial commensals. The third section describes advances in elucidating the complex path from association to function using in-depth sequencing and functional studies of the cellular and molecular effects of genes in the loci identified by genetics. The final section links our current understanding with clinically relevant questions, such as prediction, interactions with drugs or nutrients, and disease prevention, and paints a realistic but hopeful vision of the future. <.
Other form:Printed edition: 9783319015736
Standard no.:10.1007/978-3-319-01574-3
Table of Contents:
  • Part I Genetic Discovery
  • Part II Interpretation and Data Integration
  • Part III From Association to Function
  • Part IV Clinical Translation.