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|a Dendrites :
|b development and disease /
|c Kazuo Emoto, Rachel Wong, Eric Huang, Casper Hoogenraad, editors.
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|a [Tokyo] :
|b Springer,
|c 2016.
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|a 1 online resource (xxi, 714 pages) :
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|a Online resource; title from PDF title page (EBSCO, viewed August 25, 2016).
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|a Includes bibliographical references and index.
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|a Part I: Introduction; Chapter 1: Introduction; References; Part II: Basic Biology of Dendrites; Chapter 2: Cytoskeletal Organization: Actin; 2.1 The Actin Cytoskeleton in the Development and Maintenance of Dendrites; 2.1.1 Introduction to Actin; 2.1.2 The Dendritic Cytoskeleton: Actin; 2.2 The Actin Cytoskeleton in Neurological Diseases; 2.2.1 Rho GTPase Signaling in Neurological Diseases; 2.2.2 Actin-Binding Proteins in Neurological Diseases; 2.2.3 Actin Mutations in Neurological Diseases; 2.3 Final Words; References.
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|a Chapter 3: Microtubule Organization and Microtubule-Associated Proteins (MAPs)3.1 Introduction; 3.2 Organization of Axonal and Dendritic Microtubules; 3.3 Functions of Axon and Dendritic Microtubules; 3.4 Classical Maps; 3.4.1 MAP1 Family of Microtubule-Associated Proteins; 3.4.1.1 MAP1 Family Member MAP1A; 3.4.1.2 MAP1 Family Member MAP1B; 3.4.1.3 MAP1 Family Member MAP1S; 3.4.2 MAP2 Family of Microtubule-Associated Proteins; 3.4.3 MAP3/MAP4 Family of Microtubule-Associated Proteins; 3.4.4 MAP6 Family of Microtubule-Associated Proteins; 3.4.5 MAP7 Family of Microtubule-Associated Proteins.
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|a 3.4.6 MAP9 Family of Microtubule-Associated Proteins3.4.7 Tau/MAPT Family of Microtubule-Associated Proteins; 3.5 Discussion and Outlook; References; Chapter 4: Membrane Trafficking Mechanisms: Exocytosis and Endocytosis in Dendrites; 4.1 Introduction; 4.1.1 Dendrites: Form and Function; 4.1.2 Membrane Traffic in Dendrites: Challenges of Large Size and Spatial Heterogeneity; 4.1.3 Ubiquitous and Neuron-Specific Regulators of Membrane Traffic; 4.1.4 Intrinsic and Extrinsic Regulation of Dendrite Morphogenesis.
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|a 4.2 The Biosynthetic Membrane Compartments in Dendrites: Endoplasmic Reticulum, Golgi, and Trans-Golgi Network4.2.1 The Biosynthetic Pathways in Non-neuronal Cells; 4.2.1.1 The Endoplasmic Reticulum; 4.2.1.2 The ER-Golgi Transitional Compartments; 4.2.1.3 The Golgi Apparatus; 4.2.1.4 The Trans-Golgi Network (TGN); 4.2.1.5 Unconventional Secretion; 4.2.2 The Secretory Pathways in Dendrites; 4.2.2.1 Dendritic ER; 4.2.2.2 Transitional ER-Golgi Compartments in Dendrites; 4.2.2.3 Golgi Compartments in Dendrites; 4.2.2.4 Bypassing the Somatic Golgi: Secretion from Golgi Outposts.
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|a 4.2.2.5 Golgi Bypass in Neurons4.3 The Dendritic Endosomal Compartments; 4.3.1 The Endosomal Pathways in Non-neuronal Cells; 4.3.1.1 The Centrality of Endosomes to Cell Function; 4.3.1.2 The Canonical Endosomal Compartments; 4.3.2 The Endosomal Pathway in Neurons; 4.3.2.1 Spatial Heterogeneity in Endosomal Populations; 4.3.2.2 Dynamics of Dendritic Endosomes; 4.3.2.3 Directionality of Dendritic Vesicle Transport; 4.3.2.4 Exocytosis from Endosomes/Recycling in Dendrites; 4.3.2.5 Neuronal-Enriched Endosomal Proteins: Two Examples; 4.4 Conclusion; References.
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|a Studies in human patients and animal models of disease suggest a strong correlation between defects in dendrite development and common neurological disorders such as autism. Much of this book is thus dedicated toward highlighting recent advances in our understanding of the cellular and molecular mechanisms that regulate the development and maintenance of dendrites, a crucial component of neurons. The book begins by presenting the current state of knowledge on the building blocks or cell biology of dendrites. Mechanisms that sculpt the stereotypic architecture of dendritic arbors and shape their connectivity are also discussed, along with recent work describing how dendritic organization and connectivity are perturbed in disease. A unique aspect of the book is its exploration of diverse neuronal cell types across vertebrates and invertebrates, allowing a comparison of mechanisms across distinct circuits and species. The book comprises six parts, which cover the major advances in the field: Part 1, Introduction; Part 2, Basic Biology of Dendrites; Part 3, Patterning Dendritic Architecture of Neurons and Their Populations; Part 4, Cellular and Molecular Control of Dendrite Development and Maintenance; Part 5, Synapse Formation onto Dendrites; and Part 6, Dendrites in Disease. The book offers an excellent point of entry for students interested in neuroscience, as well as for clinicians.
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| 650 |
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0 |
|a Dendrites.
|0 http://id.loc.gov/authorities/subjects/sh85036698
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| 650 |
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0 |
|a Dendrites
|x Diseases.
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| 650 |
1 |
2 |
|a Dendrites.
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| 650 |
|
7 |
|a SCIENCE
|x Life Sciences
|x Zoology
|x General.
|2 bisacsh
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| 650 |
|
7 |
|a Dendrites.
|2 fast
|0 (OCoLC)fst00890267
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| 655 |
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0 |
|a Electronic books.
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| 655 |
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4 |
|a Electronic books.
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| 700 |
1 |
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|a Emoto, Kazuo,
|e editor.
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| 700 |
1 |
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|a Wong, Rachel O.,
|e editor.
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| 700 |
1 |
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|a Huang, Eric,
|e editor.
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| 700 |
1 |
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|a Hoogenraad, Casper,
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|t Dendrites.
|d [Tokyo] : Springer, 2016
|z 4431560483
|z 9784431560487
|w (OCoLC)939532064
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| 928 |
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|t Library of Congress classification
|a QP363
|l Online
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|i 12539433
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