Vaccine adjuvants : methods and protocols /
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| Imprint: | New York, NY : Humana Press : Springer, ©2017. |
|---|---|
| Description: | 1 online resource (xii, 372 pages) : illustrations (some color) |
| Language: | English |
| Series: | Methods in molecular biology, 1064-3745 ; 1494 Springer protocols Springer protocols (Series) Methods in molecular biology (Clifton, N.J.) ; v. 1494. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11267585 |
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| 245 | 0 | 0 | |a Vaccine adjuvants : |b methods and protocols / |c edited by Christopher B. Fox. |
| 260 | |a New York, NY : |b Humana Press : |b Springer, |c ©2017. | ||
| 300 | |a 1 online resource (xii, 372 pages) : |b illustrations (some color) | ||
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| 490 | 1 | |a Methods in molecular biology, |x 1064-3745 ; |v 1494 | |
| 490 | 1 | |a Springer protocols | |
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a This collection seeks to elucidate the practical methods necessary for successful adjuvant development, with a particular focus on the synthesis, formulation, manufacturing, and characterization aspects involved. Beginning with an overview and a case study, the book then delves into in silico design, chemical synthesis, biosynthesis, and/or purification from natural raw materials of specific adjuvant molecules, adjuvant formulation approaches, the analytical characterization of adjuvant formulations and adjuvant-containing vaccines, as well as the biological characterization of vaccine adjuvant activity, including in vitro and in vivo approaches, to measure innate and adaptive immune responses. Written in the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, Vaccine Adjuvants: Methods and Protocols aims to facilitate vaccine adjuvant product development efforts, making them more accessible, manufacturable, and better characterized. | ||
| 650 | 0 | |a Vaccines |x Immunology. | |
| 650 | 1 | 2 | |a Vaccines |x immunology. |
| 650 | 2 | |a Adjuvants, Immunologic |x therapeutic use. | |
| 650 | 7 | |a Immunology. |2 bicssc | |
| 650 | 7 | |a Medical |x Immunology. |2 bisacsh | |
| 655 | 2 | |a Laboratory Manual. | |
| 655 | 4 | |a Electronic books. | |
| 655 | 7 | |a Electronic books. |2 lcgft | |
| 700 | 1 | |a Fox, Christopher B. |q (Christopher Bradford), |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Vaccine adjuvants. |d New York : Humana Press : Springer, 2017 |z 9781493964437 |
| 830 | 0 | |a Springer protocols (Series) |0 http://id.loc.gov/authorities/names/no2008180772 | |
| 830 | 0 | |a Methods in molecular biology (Clifton, N.J.) ; |v v. 1494. |x 1064-3745 |0 http://id.loc.gov/authorities/names/n92002874 | |
| 880 | 0 | 0 | |6 505-00/(S |t Overview of vaccine adjuvants : introduction, history, and current status / |r Ruchi R. Shah, Kimberly J. Hassett, and Luis A. Brito -- |t Development of the CpG adjuvant 1018 : a case study / |r John D. Campbell -- |t Syntheses of human TLR8-specific small-molecule agonists / |r Mallesh Beesu, Hari Prasad Kokatla, and Sunil A. David -- |t Semisynthesis of analogues of the saponin immunoadjuvant QS-21 / |r Alberto Fernández-Tejada [and others] -- |t QS-21 adjuvant : laboratory-scale purification method and formulation into liposomes / |r Livia Brunner, Christophe Barnier-Quer, and Nicolas Collin -- |t Purification of an immunoadjuvant saponin fraction from Quillaja brasiliensis leaves by reversed-phase silica gel chromatography / |r Anna C.A. Yendo [and others] -- |t Biosynthetic approaches to squalene production : the case of yeast / |r Martin Valachovič and Ivan Hapala -- |t In silico adjuvant design and validation / |r Matthew N. Davies [and others] -- |t Manufacturing methods for liposome adjuvants / |r Yvonne Perrie [and others] -- |t Synthesis of lymph node-targeting adjuvants / |r Melissa C. Hanson and Darrell J. Irvine -- |t Preparing an adjuvanted thermoresponsive gel formulation for sublingual vaccination / |r Manjari Lal, Jessica White, and Changcheng Zhu -- |t Manufacture of oil-in-water emulsion adjuvants / |r Jean Haensler -- |t Methods to prepare aluminum salt-adjuvanted vaccines / |r Sachin G. Thakkar and Zhengrong Cui -- |t Production of adjuvant-loaded biodegradable particles for use in cancer vaccines / |r Cristina Maria de Barros [and others] -- |t Lyophilization of adjuvanted vaccines : methods for formulation of a thermostable freeze-dried product / |r Michelle Y. Chan, Timothy S. Dutill, and Ryan M. Kramer -- |t Stressed stability techniques for adjuvant formulations / |r Manvi Hasija [and others] -- |t Particle sizing of nanoparticle adjuvant formulations by dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) / |r Michelle Y. Chan [and others] -- |t Quantification of multiple components of complex aluminum-based adjuvant mixtures by using fourier transform infrared spectroscopy and partial least squares modeling / |r Quinton M. Dowling and Ryan M. Kramer -- |t Determination of protein content in Alhydrogel ® -based vaccines by O-Phthalaldehyde assay / |r Kelly M. Rausch and Daming Zhu -- |t Staining and transfer techniques for SDS-PAGE gels to minimize oil-in-water emulsion adjuvant interference / |r Alicia M. Schwartz [and others] -- |t Interactions between antigens and nanoemulsion adjuvants : separation and characterization techniques / |r Michelle Y. Chan [and others] -- |t Screening vaccine formulations in fresh human whole blood / |r Jalil Hakimi [and others] -- |t Analysis of the innate response to adjuvants : characterization of the draining lymph node by fluorescence-activated cell sorting / |r Anthony L. Desbien -- |t Assessment of antigen-specific cellular Immunogenicity Using Intracellular Cytokine Staining, ELISpot, and Culture Supernatants / |r Elyse A. Beebe and Mark T. Orr -- |t Eliciting epitope-specific CD8 T cell response by immunization with microbial protein antigens formulated with α-galactosylceramide : theory, practice, and protocols / |r Pavlo Gilchuk [and others] -- |t Molecular methods and bioinformatic tools for adjuvant characterization by high-throughput sequencing / |r Steven R. Wiley and Vanitha S. Raman. |
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