Systems biology of tumor microenvironment : quantitative modeling and simulations /
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| Imprint: | [Cham] Switzerland : Springer, [2016] ©2016 |
|---|---|
| Description: | 1 online resource (xvii, 249) : illustrations (chiefly color) |
| Language: | English |
| Series: | Advances in experimental medicine and biology, 2214-8019 ; volume 936 Advances in experimental medicine and biology ; volume 936. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11267795 |
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| 245 | 0 | 0 | |a Systems biology of tumor microenvironment : |b quantitative modeling and simulations / |c Katarzyna A. Rejniak, editor. |
| 264 | 1 | |a [Cham] Switzerland : |b Springer, |c [2016] | |
| 264 | 4 | |c ©2016 | |
| 300 | |a 1 online resource (xvii, 249) : |b illustrations (chiefly color) | ||
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| 490 | 1 | |a Advances in experimental medicine and biology, |x 2214-8019 ; |v volume 936 | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Image analysis of the tumor microenvironment / Mark C. Lloyd, Joseph O. Johnson, Agnieszka Kasprzak, Marilyn M. Bui -- Hypoxia in gliomas: opening therapeutical opportunities using a mathematical-based approach / Alicia Martı́nez-Gonz̀lez, Gabriel F. Calvo, Jose M. Ayuso, Ignacio Ochoa [and others] -- Computer simulations of the tumor vasculature: applications to interstitial fluid flow, drug delivery, and oxygen supply / Michael Welter, Heiko Rieger -- Cell-ECM interactions in tumor invasion / Xiuxiu He, Byoungkoo Lee, Yi Jiang -- Circulating tumor cells: when a solid tumor meets a fluid microenvironment / Katarzyna A. Rejniak -- Modeling proteolytically driven tumor lymphangiogenesis / Georgios Lolas, Lasse Jensen, George C. Bourantas, Vasiliki Tsikourkitoudi [and others] -- Positive feedback loops between inflammatory, bone and cancer cells during metastatic niche construction / Ardeshir Kianercy, Kenneth J. Pienta -- Microenvironmental niches and sanctuaries: a route to acquired resistance / Judith P̌rez-Vel̀zquez, Jana L. Gevertz, Aleksandra Karolak, Katarzyna A. Rejniak -- The tumor microenvironment as a barrier to cancer nanotherapy / Louis T. Curtis, Hermann B. Frieboes -- Microenvironment-mediated modeling of tumor response to vascular-targeting drugs / Jana L. Gevertz -- Optimizing chemotherapeutic anti-cancer treatment and the tumor microenvironment: an analysis of mathematical models / Urszula Ledzewicz, Heinz Schaettler -- Progress towards computational 3-D multicellular systems biology / Paul Macklin, Hermann B. Frieboes, Jessica L. Sparks, Ahmadreza Ghaffarizadeh [and others]. | |
| 588 | 0 | |a Online resource; title from pdf title page (SpringerLink, viewed October 18, 2016). | |
| 520 | |a This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology. | ||
| 650 | 0 | |a Tumors |x Microbiology |v Laboratory manuals. | |
| 650 | 0 | |a Systems biology |v Laboratory manuals. | |
| 650 | 1 | 2 | |a Tumor Microenvironment. |
| 650 | 1 | 2 | |a Systems Biology |x methods. |
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| 650 | 7 | |a Systems biology. |2 fast |0 (OCoLC)fst01745552 | |
| 655 | 4 | |a Electronic books. | |
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| 700 | 1 | |a Rejniak, Katarzyna A., |e editor. | |
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| 776 | 0 | 8 | |i Print version: |t Systems Biology of Tumor Microenvironment. |d Springer Verlag 2016 |z 9783319420219 |w (OCoLC)951761555 |
| 830 | 0 | |a Advances in experimental medicine and biology ; |v volume 936. |x 0065-2598 |0 http://id.loc.gov/authorities/names/n42001229 | |
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