Molecular and cellular biology of platelet formation : implications in health and disease /
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| Imprint: | Cham, Switzerland : Springer, [2016] ©2016 |
|---|---|
| Description: | 1 online resource : illustrations |
| Language: | English |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11271293 |
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| 245 | 0 | 0 | |a Molecular and cellular biology of platelet formation : |b implications in health and disease / |c Harald Schulze, Joseph Italiano, editors. |
| 264 | 1 | |a Cham, Switzerland : |b Springer, |c [2016] | |
| 264 | 4 | |c ©2016 | |
| 300 | |a 1 online resource : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file | ||
| 347 | |b PDF | ||
| 504 | |a Includes bibliographical references. | ||
| 588 | 0 | |a Online resource; title from PDF title page (EBSCO, viewed February 18, 2017). | |
| 505 | 0 | |a Preface; Contents; Part I: Megakaryocytes and Thrombopoiesis; 1: Megakaryopoiesis and Platelet Biogenesis; 1.1 Introduction; 1.2 Megakaryocyte Development; 1.2.1 Commitment to the Megakaryocyte Lineage; 1.2.2 Polyploidization; 1.2.3 Cytoplasmic Maturation; 1.3 Platelet Formation; 1.3.1 The Proplatelet Theory; 1.3.2 Morphogenesis of Proplatelets; 1.3.3 The Cytoskeletal Engine of Platelet Biogenesis; 1.3.3.1 Microtubules Power Proplatelet Extension; 1.3.3.2 Transport of Organelles and Granules Along Proplatelets into Assembling Platelets. | |
| 505 | 8 | |a 1.3.3.3 Actin-Driven Bending and Branching of Proplatelets1.3.3.4 The Spectrin Membrane Skeleton; 1.3.4 Release of Individual Platelets; References; 2: Transcriptional Regulation of Platelet Formation: Harnessing the Complexity for Efficient Platelet Production In Vitro; 2.1 Introduction; 2.2 Haematopoietic Stem Cell Differentiation: About Heterogeneity, Stochastic and Directed Fate Decisions; 2.3 Regulation of Gene Expression: Multilayer Complexity; 2.4 Making Platelets: The Megakaryocyte, Its Niche and Its DNA Content; 2.4.1 MK Specification and Differentiation. | |
| 505 | 8 | |a 2.4.2 Triggers for Proplatelet Formation and Platelet Release: The Little Bit We Do Know2.4.3 MK DNA Content: Does Ploidy Really Matter?; 2.5 Transcription Factors Controlling the Megakaryocyte Cell Fate; 2.5.1 The GATAs; 2.5.1.1 GATA1 and GATA2; 2.5.1.2 FOG1 and Other Partners of GATA1; 2.5.1.3 Down Syndrome and Megakaryopoiesis; 2.5.2 TAL1; 2.5.3 RUNX1; 2.5.3.1 RUNX1 and Haematopoiesis; 2.5.3.2 Familial Platelet Disorder/AML; 2.5.3.3 RUNX1 in Partnership; 2.5.4 ETS Factors; 2.5.4.1 FLI1; 2.5.4.2 ERG; 2.5.4.3 ETV6; 2.5.5 EVI1; 2.5.6 NFE2 and Related Transcription Factors. | |
| 505 | 8 | |a 2.5.6.1 NFE22.5.6.2 BACH1 and BACH2; 2.5.7 SRF and MKL1; 2.5.8 NFAT; 2.5.9 MEIS1 and Its Regulator GFI1B; 2.5.10 MYB; 2.5.11 It Is All About Networking; 2.6 Gene Regulation: A Gateway into New Biological Discoveries; 2.7 Transcription Factors and the "Making" of Platelets for Clinical Use; 2.7.1 The Clinical Need for Platelets Produced in the Laboratory; 2.7.2 Harvesting Platelets from In Vitro-Produced MKs; 2.7.3 Developmental Differences in Megakaryocytes and Platelets: Embryos Are Not Adults; 2.7.4 MKs and Platelets from Human Pluripotent Stem Cells; 2.7.5 Disease Modelling. | |
| 505 | 8 | |a 2.8 Concluding RemarksReferences; 3: Megakaryocytic Transcription Factors in Disease and Leukemia; 3.1 Introduction; 3.2 Specific Transcription Factors; 3.2.1 GATA Family Transcription Factors; 3.2.1.1 GATA-1; 3.2.1.2 GATA-2; 3.2.1.3 ZFPM1 (Previously Called Friend of GATA-1 (FOG1)); 3.2.1.4 GATA Factor Mutations in Human Congenital Thrombocytopenias; 3.2.1.5 GATA-1 Mutations in Down Syndrome Transient Myeloproliferative Disorder and Acute Megakaryoblastic Leukemia; 3.2.1.6 GATA-2 Mutations in Familial Myelodysplastic Syndrome and Acute Myelogenous Leukemia. | |
| 520 | |a This book gives a comprehensive insight into platelet biogenesis, platelet signal transduction, involvement of platelets in disease, the use of diverse animal models for platelet research and future perspectives in regard to platelet production and gene therapy. Being written by international experts, the book is a concise state-of-the art work in the field of platelet biogenesis, biology and research. It represents an indispensable tool for research scientists in biomedicine, vascular biology, hematopoiesis and hemostasis and specifically for scientists in platelet research, as well as for clinicians in the field of hematology and transfusion medicine. | ||
| 650 | 0 | |a Blood platelets. |0 http://id.loc.gov/authorities/subjects/sh85015006 | |
| 650 | 2 | |a Blood Platelets. | |
| 650 | 7 | |a Haematology. |2 bicssc | |
| 650 | 7 | |a Cellular biology (cytology) |2 bicssc | |
| 650 | 7 | |a Medical genetics. |2 bicssc | |
| 650 | 7 | |a Medical research. |2 bicssc | |
| 650 | 7 | |a Physiology. |2 bicssc | |
| 650 | 7 | |a MEDICAL |x Physiology. |2 bisacsh | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Human Anatomy & Physiology. |2 bisacsh | |
| 650 | 7 | |a Blood platelets. |2 fast |0 (OCoLC)fst00834782 | |
| 655 | 4 | |a Electronic books. | |
| 700 | 1 | |a Schulze, Harald, |e editor. | |
| 700 | 1 | |a Italiano, Joseph, |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Molecular and cellular biology of platelet formation. |d Cham, Switzerland : Springer, [2016] |z 9783319395609 |z 3319395602 |w (OCoLC)948561589 |
| 903 | |a HeVa | ||
| 929 | |a oclccm | ||
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| 928 | |t Library of Congress classification |a QP97 |l Online |c UC-FullText |u https://link.springer.com/10.1007/978-3-319-39562-3 |z Springer Nature |g ebooks |i 12543903 | ||