Translational immunotherapy of brain tumors /
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| Imprint: | London, United Kingdom : Academic Press, an imprint of Elsevier, 2017. |
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| Description: | 1 online resource. |
| Language: | English |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11271613 |
Table of Contents:
- Front Cover; TRANSLATIONALIMMUNOTHERAPY OFBRAIN TUMORS; TRANSLATIONALIMMUNOTHERAPYOF BRAINTUMORS; Copyright; Contents; List of Contributors; Introduction to Translational Immunotherapy for Brain Tumors; TRANSLATIONAL IMMUNOTHERAPY FOR BRAIN TUMORS SUMMARY; PRIMER ON MALIGNANT GLIOMAS; THE POTENTIAL OF CANCER IMMUNOTHERAPY; CHALLENGES OF BRAIN TUMOR IMMUNOTHERAPY; CHAPTER OVERVIEW; References; I
- IIMMUNOLOGICALFEATURES OF BRAINTUMORS; 1
- An Introduction to Immunotherapy in the Treatment of Brain Tumors; INTRODUCTION; THE IMMUNE RESPONSE; IMMUNE TOLERANCE
- UNIQUE ASPECTS OF THE CENTRAL NERVOUS SYSTEM IMMUNE RESPONSEThe Blood-Brain Barrier; The CNS Lymphatic System; Antigen Presentation in the CNS; CANCER IMMUNOTHERAPIES; References; 2
- Immune Constitution of Patients With Brain Tumors; BACKGROUND AND DISCOVERY; CURRENT UNDERSTANDING: ANALYZING SYSTEMIC IMMUNE DYSFUNCTION; Lymphopenia; Lymphocyte Dysfunction; Regulatory T Cells; CURRENT UNDERSTANDING: ANALYZING THE TUMOR; Cytokine Dysregulation; Signal Transducer and Activator of Transcription-3; Indoleamine 2,3 Dioxygenase; CLINICAL OPPORTUNITIES
- Countering T Cell Dysfunction: Immune Checkpoint BlockadeCountering Regulatory T Cells and Lymphopenia; Countering Cytokine Dysregulation; Countering Tumor STAT3 and IDO Expression; CONCLUSION; References; 3
- The Role of Regulatory T Cells and Indoleamine-2,3-dioxygenase in Brain Tumor Immunosuppression; BACKGROUND AND DISCOVERY; ORIGIN OF TREGS; FUNCTION OF TREGS; TREGS IN THE CANCER IMMUNITY CYCLE; TREGS AND GLIOMA; TRYPTOPHAN CATABOLISM IN IMMUNITY AND IN CANCER; IDO1, IDO2, AND TDO; THE AHR; MECHANISMS OF IMMUNE REGULATION BY THE IDO PATHWAY; THE IDO PATHWAY IN CANCER AND IN GLIOMA
- TARGETING TREGS IN PRECLINICAL MODELTARGETING IDO IN PRECLINICAL MODELS; CLINICAL TRIAL DATA; CONCLUSION; References; 4
- The Role of Myeloid-Derived Suppressor Cells in Immunosuppression in Brain Tumors; BACKGROUND AND DISCOVERY OF THE MYELOID CELL; MDSCs in Mice; MDSCs in Humans; MDSC Activation, Proliferation, Migration, and Expansion; Suppressive Mechanisms Mediated by MDSCs; Suppression via Arg1 and iNOS; Suppression via Reactive Oxygen Species; Suppression via Peroxynitrite; Other Immunosuppressive Mechanisms; MDSCs in Glioma Development; PRECLINICAL DATA: TARGETING THE MDSC POPULATION