Immunopathology in toxicology and drug development. Volume 1, Immunobiology, investigative techniques, and special studies /

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Bibliographic Details
Imprint:	Cham, Switzerland : Humana Press, [2017] ©2017
Description:	1 online resource : illustrations
Language:	English
Series:	Molecular and integrative toxicology Molecular and integrative toxicology.
Subject:	Immunopathology. Immune System -- pathology. Immunopathology.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11272795

Hidden Bibliographic Details
Varying Form of Title:	Immunobiology, investigative techniques, and special studies
Other authors / contributors:	Parker, George A., editor.
ISBN:	9783319473772 3319473778 9783319473758 3319473751 3319473840 9783319473840
Digital file characteristics:	text file PDF
Notes:	Includes bibliographical references and index. Vendor-supplied metadata.
Summary:	This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems, offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.
Other form:	Print version: Immunopathology in toxicology and drug development. Volume 1, Immunobiology, investigative techniques, and special studies. Cham, Switzerland : Humana Press, [2017] 9783319473758 3319473751
Standard no.:	10.1007/978-3-319-47377-2

Table of Contents:

Basic Immunobiology
Cells of the Immune System
Signaling and effector molecules in immunity
Development of immune system organs
Aging of immune system organs
Flow cytometry and immunophenotyping in drug development
Pathology evaluation for detection of immunomodulation
Enhanced immunohistopathology
Clinical Pathology Assays in Immunopathology
Application of immunohistochemistry in toxicologic pathology of the hematolymphoid system
Morphometry and stereology in immunopathology
Molecular techniques in immunopathology
Current issues in developmental immunotoxicity
The Murine local lymph node assay
Host Resistance assays for efficacy and immunotoxicology safety evaluations.

Immunopathology in toxicology and drug development. Volume 1, Immunobiology, investigative techniques, and special studies /

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