Modern tools of biophysics. Volume 5 /
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| Imprint: | New York, NY : Springer, 2017. |
|---|---|
| Description: | 1 online resource |
| Language: | English |
| Series: | Handbook of modern biophysics Handbook of modern biophysics. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11273674 |
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| 245 | 0 | 0 | |a Modern tools of biophysics. |n Volume 5 / |c Thomas Jue, editor. |
| 264 | 1 | |a New York, NY : |b Springer, |c 2017. | |
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| 490 | 1 | |a Handbook of modern biophysics | |
| 505 | 0 | |a Preface; Contents; Contributors; 1: Wave Theory of Image Formation in a Microscope: Basic Theory and Experiments; 1.1 Introduction; 1.2 Philosophy of This Chapter; 1.3 Building the Demonstration Apparatus; 1.4 Fundamental Concept: The Huygens-Fresnel Principle; 1.5 Diffraction from an Arbitrary Distribution of Scatterers; 1.6 Forming an Image: The Double Fourier Transform; 1.7 Sharpness of the Image and Resolution; 1.8 Summary; Problems; Solution; Further Study; References; 2: Recording of Ionic Currents Under Physiological Conditions: Action Potential-Clamp and Onion-Peeling Techniques | |
| 505 | 8 | |a 2.1 Introduction2.2 The Principles of the AP-Clamp Technique; 2.3 A Short Historical Review; 2.4 Variations of the AP-Clamp Technique; 2.4.1 Using `Typical ́or `Standardized ́AP; 2.4.2 Using `Modified ́or `Reconstructed ́AP; 2.4.3 Dynamic Clamp; 2.4.4 The selfAP-Clamp Technique; 2.4.5 The AP-Clamp Sequential Dissection or `Onion-Peeling ́Technique; 2.5 Applications of the AP-Clamp Methods; 2.5.1 Study of the Individual Cell Electrophysiology (ICE); 2.5.2 Mapping the Regional and Transmural Differences; 2.5.3 Studying the Complex Effects of Pathological Conditions | |
| 505 | 8 | |a 2.5.4 Characterization of Drug Effects2.6 Technical Aspects; 2.6.1 Cell Quality and the Solutions; 2.6.2 The Patch Pipette and the Whole-Cell Seal Configuration; 2.6.3 Instrumentation; 2.7 Channel Inhibitors; 2.8 Conclusion; Problems; Solutions; Further Study; References; 3: Patch Clamp Technique and Applications; 3.1 Introduction; 3.2 Basic Recording Setup; 3.3 Patch Clamp Configurations; 3.4 Seal Resistance; 3.5 Series Resistance; 3.6 Sources of Noise; 3.7 Current Clamp Mode; 3.8 Voltage Clamp Mode; 3.9 Summary; Problem; Solution; Further Study; References | |
| 505 | 8 | |a 4: Structural Insights from Membrane Small-Angle X-ray Diffraction with Anomalous X-ray Scattering4.1 Introduction; 4.2 Background; 4.3 Membrane Diffraction; 4.4 The Physics of Anomalous Scattering; 4.5 Small-Angle X-ray Scattering from AChR-Enriched Membranes; 4.6 Summary and Future Work; Problems; Solutions; Thoughts on Problem 1; Thoughts on Problem 2; Thoughts on Problem 3; Further Study; References; 5: Computer Simulations and Nonlinear Dynamics of Cardiac Action Potentials; 5.1 Introduction; 5.2 Cardiac Action Potential; 5.3 Modeling of Cell Membrane and Channel Gating | |
| 505 | 8 | |a 5.4 Single Cell Simulation5.5 APD Restitution and Alternans; 5.6 Cardiac Tissue; 5.7 Tissue Simulation: 1D Cable; 5.8 Tissue Simulation: Spatially Discordant Alternans; 5.9 Tissue Simulation: 2D Tissue; 5.10 Ventricular Tachycardia and Fibrillation; 5.11 Parallel Computing (OpenMP); 5.12 Parallel Computing (CUDA); 5.13 Summary; Problems; Solutions; Further Study; References; 6: Hemoglobin and Myoglobin Contribution to the NIRS Signal in Skeletal Muscle; 6.1 Introduction; 6.2 Near-Infrared Spectroscopy; 6.3 Source of the NIRS Signal in Skeletal Muscle | |
| 500 | |a Includes index. | ||
| 588 | 0 | |a Online resource; title from PDF title page (SpringerLink, viewed May 23, 2017). | |
| 520 | |a Handbook of Modern Biophysics brings current biophysics topics into focus, so that biology, medical, engineering, mathematics, and physical-science students or researchers can learn fun¬damental concepts and the application of new techniques in addressing biomedical challenges. Chapters will develop the conceptual framework of the physics formalism and illustrate the biomedical applica¬tions. With the addition of problem sets, guides to further study, and references, the interested reader can continue to independently explore the ideas presented. Volume 5: Modern Tools of Biophysics Editor: Thomas Jue, PhD In Modern Tools of Biophysics, a group of prominent professors have provided insights into the tools used in biophysics with respect to the following topics: Wave Theory of Image Formation in a Microscope: Basic Theory and Experiments Computer Simulations and Nonlinear Dynamics of Cardiac Action Potentials Myoglobin and Hemoglobin Contribution to the NIRS Signal in Muscle Anomalous Low Angle X-Ray Scattering of Membrane with Lanthanides Recording of Ionic Currents under Physiological Conditions--Action Potential-Clamping and "Onion-Peeling" Techniques Patch Clamp Technique and Applications About the Editor Thomas Jue is a Professor in the Department of Biochemistry and Molecular Medicine at the University of California, Davis. He is an internationally recognized expert in developing and applying magnetic resonance techniques to study animal as well as human physiology in vivo and has published extensively in the field of magnetic resonance spectroscopy and imaging, near-infrared spectroscopy, bioenergetics, cardiovascular regulation, exercise, and marine biology. He served as a Chair of the Biophysics Graduate Group Program at UC Davis, where he started to develop scholarly approaches to educate graduate students with a balance of physical-science/mathematics formalism and biomedical perspective in order to promote interest at the interface of physical science, engineering, mathematics, biology, and medicine. He continues to develop the biophysics curriculum, and the Handbook of Modern Biophysics represents an aspect of that effort. | ||
| 650 | 0 | |a Biophysics. |0 http://id.loc.gov/authorities/subjects/sh85014253 | |
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