Cell biology of herpes viruses /
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Imprint: | Cham, Switzerland : Springer, 2017. |
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Description: | 1 online resource : illustrations |
Language: | English |
Series: | Advances in anatomy, embryology and cell biology, 0301-5556 ; 223 Advances in anatomy, embryology, and cell biology ; 223. |
Subject: | |
Format: | E-Resource Book |
URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11274117 |
Table of Contents:
- Preface; References; Contents; Chapter 1: Initial Contact: The First Steps in Herpesvirus Entry; 1.1 Introduction; 1.2 Attachment to Cells; 1.3 Receptor Binding; 1.3.1 gD-Binding Receptors; 1.3.1.1 Herpes Simplex Viruses; 1.3.1.2 Equine Herpesviruses; 1.3.2 gB-Binding Receptors; 1.3.3 gH/gL-Binding Receptors; 1.3.4 gE-Binding Receptors; 1.4 Signaling Triggered by Alphaherpesvirus Binding to Cellular Receptors; 1.5 Calcium-Signaling Pathways; 1.6 Small GTPases; 1.7 Model of Entry: Refinement; 1.8 Conclusion and Remarks; References; Chapter 2: Herpes simplex virus Membrane Fusion.
- 2.1 Introduction2.2 Types of Fusion Mediated by HSV Glycoproteins; 2.2.1 Virus-Cell Fusion During Entry; 2.2.2 Fusion of Primary Enveloped HSV-1 with the Outer Nuclear Membrane; 2.2.3 HSV Syncytium Formation; 2.2.4 Fusion from Without; 2.2.5 Transfected Cell Fusion; 2.3 Summary and Future Directions; References; Chapter 3: Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease; 3.1 Introduction; 3.1.1 Pattern Recognition Receptors, Signaling, and Effector Pathways; 3.2 Sensing and Signaling Pathways; 3.2.1 Sensing of Virion and Infected Cell Proteins; 3.2.2 Sensing of HSV DNA.
- 3.2.3 PYHIN (PYRIN and HIN Domain) Family Proteins3.2.4 Sensing of HSV RNA; 3.2.5 Sensing of Viral Fusion; 3.3 Cellular Effector Mechanisms; 3.4 Viral Evasion; 3.5 Mechanisms in Animal Models; 3.6 Manifestations in Humans; 3.6.1 Perspective; References; Chapter 4: The Human CMV IE1 Protein: An Offender of PML Nuclear Bodies; 4.1 Introduction; 4.2 PML-NBs and Intrinsic Immunity; 4.2.1 Architecture of PML-NBs; 4.2.2 Repression of HCMV Transcription by PML-NB Components; 4.3 PML-NBs as Co-regulatory Structures of Innate Immune Responses.
- 4.4 IE1 as an Antagonist of Intrinsic and Innate Immune Responses4.4.1 Expression and Importance of IE1 During Lytic Infection; 4.4.2 Structure of IE1; 4.4.3 Molecular Mechanism of IE1-Mediated PML-NB Antagonization; 4.5 Summary and Outlook; References; Chapter 5: Herpesvirus Latency: On the Importance of Positioning Oneself; 5.1 Introduction; 5.2 Interaction Between Latent Viral Genomes and Chromosomal Regions; 5.2.1 Integration in the Host Cell Genome; 5.2.2 Chromosome Anchoring; 5.2.3 Centromere/Pericentromere Deposition; 5.3 Viral Genomes and PML-NBs: Janus-Faced Nuclear Bodies.
- 5.4 PML-NB Entrapment of HSV-1 Genomes During Latency/Quiescence5.5 Conclusion; References; Chapter 6: Herpesvirus Capsid Assembly and DNA Packaging; 6.1 The Herpesvirus Virion; 6.2 Capsid Assembly; 6.3 DNA Packaging; 6.4 Model of HSV DNA Packaging; 6.5 Conclusions and Outlook; References; Chapter 7: Herpesvirus Nuclear Egress; 7.1 Overview of the Nuclear Egress Process; 7.2 The Nuclear Egress Complex (NEC); 7.3 Interaction of pUL31 and pUL34 and Localization of the Nuclear Egress Complex; 7.4 Changes in Overall Nuclear Architecture.