Live variola virus : considerations for continuing research /

Live variola virus : considerations for continuing research /

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Bibliographic Details
Imprint:	Washington, D.C. : National Academies Press, ©2009.
Description:	1 online resource (xvii, 151 pages) : illustrations (some color)
Language:	English
Subject:	Smallpox -- Research. Smallpox -- Prevention. Smallpox vaccine. Virology -- Cultures and culture media. Variola virus. Biomedical Research. Research. Smallpox. Smallpox -- prevention & control. Smallpox -- therapy. Smallpox -- Prevention. Smallpox vaccine. Virology -- Cultures and culture media. Electronic books.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11280961

Hidden Bibliographic Details
Other authors / contributors:	Arvin, Ann M. Patel, Deepali. Institute of Medicine (U.S.). Committee on the Assessment of Future Scientific Needs for Live Variola Virus.
ISBN:	9780309136914 0309136911 1282412566 9781282412569 0309136903 9780309136907
Notes:	Includes bibliographical references. Print version record.
Summary:	Smallpox was a devastating disease that decimated human populations for centuries, and its eradication in 1980 was a monumental achievement for the global health community. Since then the remaining known strains of its causative agent, variola virus, have been contained in two World Health Organization (WHO)-approved repositories. In 1999, the World Health Assembly (WHA) debated the issue of destroying these remaining strains. Arguments were presented on the need to retain the live virus for use in additional important research, and the decision to destroy the virus was deferred until this research could be completed. In that same year, the Institute of Medicine (IOM) convened a consensus committee to explore scientific needs for the live virus. In the ten years since the first IOM report, the scientific, political, and regulatory environments have changed. In this new climate, the IOM was once again tasked to consider scientific needs for live variola virus. The committee evaluated the scientific need for live variola virus in four areas: development of therapeutics, development of vaccines, genomic analysis, and discovery research.
Other form:	Print version: Live variola virus. Washington, D.C. : National Academies Press, ©2009 9780309136907

Table of Contents:

Introduction
Overview of smallpox and its surveillance and control
Comparative poxvirology
Animal models using variola and other orthopoxvirses
Genomic analysis
Development of therapeutics
Development of vaccines
Methods for detection and diagnosis
Discovery research
Conclusions and recommendations.