Multi-drug resistance in cancer /

Multi-drug resistance in cancer /

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Bibliographic Details
Imprint:New York, N.Y. : Humana Press, ©2010.
Description:1 online resource (xi, 492 pages) : illustrations (some color)
Language:English
Series:Springer Protocols
Methods in molecular biology, 1940-6029 ; 596
Springer protocols (Series)
Methods in molecular biology (Clifton, N.J.) ; v. 596.
Subject:
Drug resistance in cancer cells.
Multidrug resistance.
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Neoplasms -- drug therapy
Drug resistance in cancer cells
Multidrug resistance
Laboratory Manual
Laboratory manuals.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11281167
Hidden Bibliographic Details
Other authors / contributors:Zhou, Jun.
ISBN:9781607614166
1607614162
9781607614159
1607614154
Notes:Title from PDF title page (viewed December 9, 2009).
Includes bibliographical references and index.
English.
Summary:With the devastating complication of cancer cells becoming simultaneously resistant to many structurally and mechanistically unrelated drugs, the efficacy of chemotherapeutic management of cancer often becomes severely limited. In Multi-Drug Resistance in Cancer, leading researchers in the field provide comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance protein, to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The extensive volume also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression, as well as techniques for detection and imaging of drug transporters, methods for investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. As a volume in the highly successful Methods in Molecular Biology series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Multi-Drug Resistance in Cancer offers a state-of-art collection of reviews and methods for both basic and clinician investigators who are interested in the vital study of cancer multi-drug resistance mechanisms and reversal strategies.
Other form:9781607614159
Standard no.:10.1007/978-1-60761-416-6.
Table of Contents:
  • Multidrug resistance in cancer / Bruce C. Baguley
  • Multidrug resistance in oncology and beyond : from imaging of drug efflux pumps to cellular drug targets / Wouter B. Nagengast [and others]
  • Studying drug resistance using genetically engineered mouse models for breast cancer / Sven Rottenberg, Marina Pajic, and Jos Jonkers
  • Mechanisms of multidrug resistance in cancer / Jean-Pierre Gillet and Michael M. Gottesman
  • Molecular mechanisms of drug resistance in single-step and multi-step drug-selected cancer cells / Anna Maria Calcagno and Suresh V. Ambudkar
  • Pharmacogenetics of ATP-binding cassette transporters and clinical implications / Ingolf Cascorbi and Sierk Haenisch
  • Flow cytometric evaluation of multidrug resistance proteins / Adorjan Aszalos and Barbara J. Taylor
  • Targeted chemotherapy in drug-resistant tumors, noninvasive imaging of P-glycoprotein-mediated functional transport in cancer, and emerging role of pgp in neurodagenerative [sic] diseases / Jothilingam Sivapackiam [and others]
  • Epigenetic regulation of multidrug resistance 1 gene expression : profiling CpG methylation status using bisulphite sequencing / Emma K. Baker and Assam El-Osta
  • Expression and function of P-glycoprotein in normal tissues : effect on pharmacokinetics / Frantisek Staud [and others]
  • Molecular mechanism of ATP-dependent solute transport by multidrug resistance-associated protein 1 / Xiu-bao Chang
  • Impact of breast cancer resistance protein on cancer treatment outcomes / Douglas D. Ross and Takeo Nakanishi
  • Drug ratio-dependent antagonism : a new category of multidrug resistance and strategies for its circumvention / Troy O. Harasym, Barry D. Liboiron, and Lawrence D. Mayer
  • Reversing agents for ATP-binding cassette drug transporters / Chow H. Lee
  • Overcoming multidrug resistance in cancer : clinical studies of P-glycoprotein inhibitors / Helen M. Coley
  • Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation / Jeannie M. Padowski and Gary M. Pollack
  • Examination of CYP3A and P-glycoprotein-mediated drug-drug interactions using animal models / Punit H. Marathe and A. David Rodrigues
  • Generating inhibitors of P-glycoprotein : where to, now? / Emily Crowley, Christopher A. McDevitt, and Richard Callaghan
  • Immunosuppressors as multidrug resistance reversal agents / Hamid Morjani and Claudie Madoulet
  • Overcoming multidrug resistance by RNA interference / Alexandra Stege, Andrea Krühn, and Hermann Lage
  • Circumventing tumor resistance to chemotherapy by nanotechnology / Xing-Jie Liang [and others].

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