Patient-derived xenograft models of human cancer /

Patient-derived xenograft models of human cancer /

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Bibliographic Details
Imprint:[Place of publication not identified] : Springer Verlag, 2017.
Description:1 online resource
Language:English
Series:Molecular and translational medicine
Molecular and translational medicine.
Subject:
Cancer -- Simulation methods.
Cancer -- Research.
Neoplasms
Cancer -- Research.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11308479
Hidden Bibliographic Details
Other authors / contributors:Wang, Yuzhuo, editor
Lin, Dong, editor
Gout, Peter W., editor
ISBN:9783319558257
3319558250
9783319857589
3319857584
9783319558264
3319558269
9783319558240
3319558242
Digital file characteristics:text file
PDF
Summary:This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text. Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.
Other form:Print version: Patient-derived xenograft models of human cancer. [Place of publication not identified] : Springer Verlag, 2017 9783319558240 3319558242
Standard no.:10.1007/978-3-319-55825-7
Table of Contents:
  • Introduction
  • History and Evolution of PDX Cancer Models
  • Establishment and Characterization of PDX Models
  • Methods of Generating PDX Models
  • Fidelity and Stability of PDX Models
  • Applications of PDX Models
  • Studies of Cancer Heterogeneity
  • PDX and Cancer Stem Cells
  • Modeling Cancer Metastasis
  • Modeling Drug Resistance
  • PDX and Biomarker Development
  • PDX and Preclinical Drug Screening
  • Co-clinical Trials and Personalized Cancer Therapy/Precision Medicine
  • Epilogue
  • Future Perspective.

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