Cardiac regeneration /

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Bibliographic Details
Imprint:	Cham : Springer, 2017.
Description:	1 online resource
Language:	English
Series:	Cardiac and vascular biology Cardiac and vascular biology.
Subject:	Cardiology. Heart -- Diseases -- Treatment. Regenerative medicine. Cardiology. Heart -- Diseases -- Treatment. Regenerative medicine.
Format:	E-Resource Book
URL for this record:	http://pi.lib.uchicago.edu/1001/cat/bib/11384892

Hidden Bibliographic Details
Other authors / contributors:	Ieda, Masaki, editor. Zimmermann, Wolfram-Hubertus, editor.
ISBN:	9783319561066 3319561065 9783319561042 3319561049
Digital file characteristics:	text file PDF
Notes:	Includes bibliographical references. Online resource; title from PDF title page (EBSCO, viewed November 3, 2017).
Summary:	This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
Other form:	Print version: Cardiac regeneration. Cham : Springer, 2017 9783319561042 3319561049
Standard no.:	10.1007/978-3-319-56106-6

Table of Contents:

Preface
Contents
1: Past andÂ Future ofÂ Cell-Based Heart Repair
1.1 Introduction
1.2 Cell Therapy forÂ Cardiac Repair
1.2.1 Skeletal Myoblasts
1.2.2 Bone Marrow-Derived Stem Cells
1.2.3 Endothelial Progenitors
1.2.4 Mesenchymal Stem Cells
1.2.5 Endogenous Cardiac Stem Cells
1.2.5.1 C-kitÂ +Â Cardiac Progenitors
1.2.5.2 Cardiosphere andÂ Cardiosphere-Derived Cells
1.2.5.3 Side Population Cells
1.2.5.4 Sca1+ Cardiac Progenitors
1.2.5.5 Islet1+ Cardiac Progenitors
1.2.5.6 Epicardial Progenitors
1.2.6 ES-Derived Cardiomyocytes1.2.7 Induced Pluripotent Stem Cells andÂ Reprogramming
1.2.7.1 iPSCs
1.2.7.2 Direct Reprogramming into Cardiomyocytes
1.3 Future ofÂ Cell Therapy
References
2: Progenitor Cells fromÂ theÂ Adult Heart
2.1 Phenotype andÂ Characteristics ofÂ eCSCs
2.1.1 c-kitpos Stem andÂ Progenitor Cells
2.1.2 Sca-1pos andÂ Side Population Progenitor Cells
2.2 Cardiac Differentiation Potential ofÂ eCSCs
2.3 The Controversy
2.4 Origin ofÂ eCSCs
2.5 Impact ofÂ Ageing andÂ Senescence onÂ eCSCs
2.6 Therapeutic Targets toÂ Activate eCSCs andÂ Reverse theÂ Senescent, Dysfunctional eCSC PhenotypeReferences
3: Epicardial Progenitors inÂ theÂ Embryonic andÂ Adult Heart
3.1 Epicardial Development Across Species
3.2 EPDC Derivatives andÂ Epicardial Heterogeneity
3.2.1 Epicardium Contribution toÂ Coronary Endothelial Cells
3.2.2 Epicardial Contribution toÂ Cardiomyocytes
3.2.3 Epicardial Contribution toÂ Fat Cells
3.3 The Epicardium asÂ aÂ Signaling Center inÂ theÂ Developing Heart
3.3.1 Epicardial Signals Promoting Cardiomyocyte Proliferation3.3.2 Epicardial Signals Directing Coronary Angiogenesis
3.3.3 Other Epicardial Signals Contributing toÂ Heart Development
3.4 Adult Epicardium
3.4.1 Physiological Role ofÂ theÂ Epicardium inÂ Homeostatic Conditions
3.4.2 The Epicardium toÂ Regenerate theÂ Adult Heart
3.5 Human Epicardium
References
4: Generation andÂ Application ofÂ Human Pluripotent Stem Cell-Derived Cardiomyocytes
4.1 Introduction
4.2 Applications
4.2.1 Regenerative Medicine
4.2.2 Biological Pacemaker Development4.2.3 Understanding ofÂ Human Cardiac Development
4.2.4 Disease Modeling
4.2.5 Drug Discovery, Pharmacogenomics, andÂ Cardiotoxicity Screening
4.3 Cardiomyogenesis duringÂ Mammalian Heart Development
4.4 Control ofÂ theÂ Pluripotent State
4.5 Human Pluripotent Growth Media
4.6 Priming forÂ Cardiac Differentiation
4.7 Maintenance ofÂ hiPSC-Derived Mesodermal Intermediates andÂ Cardiac Progenitor Cells
4.8 Directed Cardiac Differentiation ofÂ Human PluripotentÂ Stem Cells

Cardiac regeneration /

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