DNA methylation : patterns, functions and roles in disease /
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| Imprint: | New York : Nova Biomedical, [2016] |
|---|---|
| Description: | 1 online resource. |
| Language: | English |
| Series: | Genetics - research and issues Genetics--research and issues series. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11408450 |
Table of Contents:
- Preface; Chapter 1; Disruption of DNA Methylation Patterns Caused by Exposure to Environmental Factors during the Developmental Period; Abstract; Introduction; Endocrine-Disrupting Chemicals; Heavy Metals; Particulate Matter; Food and Alcohol Intake; Cigarette Smoke; Possible Mechanism of Dysregulation of DNA Methylation; Conclusion; Acknowledgments; References; Chapter 2; Cytosine Modifications Affect Biological Significance by a Multifactorial Network; Abstract; Abbreviations; 1. Introduction; 2. Structures of Cytosine Modifications and Active Demethylation Process
- 3. Classification of DNA Methylation in Terms of Genetic Materials and Genomic Regions3.1. Nucleic Acid Type; 3.1.1. Nuclear DNA Methylation; 3.1.2. Organelle DNA Methylation; 3.1.3. RNA Methylation; 3.2. Cytosine-Guanine (CpG) Repeats; 3.2.1. CpG Content; 3.2.2. CpG Islands; 3.3. Intergenic Locations; 4. 3D DNA Structure and Interaction with Methylation; 5. Chemical Characteristics of DNA and Its Relation with Methylation; 6. Proteins Binding to Methylated DNA; 6.1. Methylated DNA-Specific Proteins; 6.1.1. MBD Proteins; 6.1.2. Kaiso-Like Zinc Finger Protein Group
- 6.1.3. Set and Ring Finger-Associated (SRA) Domain Proteins6.2. Relationship between Methyl-Binding Proteins and DNA Methylation in Different Genomic Regions; 6.3. Histones; 6.4. Transcription Factors; 7. Biological Significance of Cytosine Modifications; 7.1. In Eukaryotes; 7.2. In Prokaryotes; Conclusion; References; Biographical Sketch; Chapter 3; Targeting Aberrant IGF2 Epigenetics as a Novel Anti-Tumor Approach; Abstract; Introduction; Loss of IGF2 Imprinting as a Molecular Hallmark in Tumors; Epigenetic Mechanisms Underlying Loss of IGF2 Imprinting in Tumors
- Correction of Aberrant Imprinting by Polycomb Repressive Complex 2 Docking Factor SUZ12An Oncolytic Viral Therapy Using the IGF2/H19 Enhancer-Insulator-Promoter System; Conclusion; Acknowledgments; References; Bibliography; Related Nova Publications; DNA Methylation: Principles, Mechanisms and Challenges; Global DNA Methylation in Obesity, Diabetes and Cardiovascular Diseases and the Influence of Environmental Factors*; The Link between MTHFR C677T Polymorphism, Folate Metabolism and Global DNA Methylation: A Literature Review*
- The Role of DNA Methylation in the Genetics and Epigenetics of Multiple Myeloma*Detecting DNA Methylation for Cancer Diagnostics and Prognostics*; Index