Immune hematology : diagnosis and management of autoimmune cytopenias /

Immune hematology : diagnosis and management of autoimmune cytopenias /

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Bibliographic Details
Imprint:Cham, Switzerland : Springer, ©2018.
Description:1 online resource : illustrations
Language:English
Subject:
Autoimmune diseases -- Diagnosis.
Immunology.
Hematology.
Autoimmune diseases -- Diagnosis.
Hematology.
Immunology.
Format: E-Resource Book
URL for this record:http://pi.lib.uchicago.edu/1001/cat/bib/11654986
Hidden Bibliographic Details
Other authors / contributors:Despotovic, Jenny M.
ISBN:9783319732695
3319732692
3319732684
9783319732688
Digital file characteristics:text file PDF
Notes:Includes bibliographical references and index.
Print version record.
Summary:This text provides a concise yet comprehensive overview of the most common autoimmune cytopenias affecting adults and children. The book is divided into four sections, each of which focuses on a major autoimmune cytopenia. The first section features background, pathophysiology, presentation, evaluation, and treatment strategies for immune thrombocytopenia (ITP), the most common cause of antibody-mediated platelet destruction. The second section reviews common forms and treatment strategies for autoimmune hemolytic anemia (AIHA), including a chapter dedicated specifically to Evans Syndrome. The third section comprehensively reviews the pathophysiology, diagnosis and current management approaches to thrombotic thrombocytopenic purpura (TTP), a potentially life-threatening autoimmune syndrome. The book concludes with a final section on autoimmune neutropenia. Each section includes a review of common underlying systemic autoimmune conditions and immune deficiency syndromes that can accompany or cause autoimmune cytopenias. Written by experts in each content area, Immune Hematology: Diagnosis and Management of Autoimmune Cytopenias is a valuable resource for clinicians and professionals who treat patients afflicted with autoimmune cytopenias, including primary care providers, hematologist/oncologists, immunologists, among others.
Other form:Print version: 3319732684 9783319732688
Standard no.:10.1007/978-3-319-73269-5
Table of Contents:
  • Intro; Preface; Contents; Contributors; Part I: Immune Thrombocytopenia (ITP); Chapter 1: Background of Immune Thrombocytopenia; Introduction; Historical Perspective; Terminology; Presentation; Primary ITP and Secondary ITP; Differential Diagnosis; Conclusion; References; Chapter 2: Pathophysiology of Immune Thrombocytopenia; Platelet Autoantibodies; Balance of Platelet Destruction and Production; Abnormal Megakaryocyte Morphology; Antibody Destruction of Megakaryocytes; Inadequate Thrombopoietin Levels; T Cell-Mediated ITP; T Cell-Propagated Autoantibody Production; Helper T Cell Responses.
  • Role of Th17 CellsRegulatory T cells; B Cell-Mediated ITP; B-Regulatory Cells; Myeloid-Derived Suppressor Cells; Genetic Studies; Secondary ITP; Helicobacter pylori-Related ITP; CMV-Related ITP; Varicella Zoster-Related ITP; Hepatitis C-Related ITP; HIV-Related ITP; Malignancy-Related ITP; Other Autoimmune Disorders; Evans Syndrome; Autoimmune Lymphoproliferative Syndrome (ALPS); References; Chapter 3: Presentation and Evaluation of Immune Thrombocytopenia; Introduction; Clinical Presentation; History; Physical Examination; Bleeding Assessment; Initial Diagnostic Investigations.
  • Diagnostic ApproachAdditional Testing for Suspected ITP; The Role of Bone Marrow Testing; Platelet Antibody Testing; Screening Tests for Associated Conditions; Infectious Triggers for ITP: Hepatitis C, HIV, and H. pylori; Autoimmune Conditions; Immunodeficiencies; Summary; References; Chapter 4: The Treatment of Immune Thrombocytopenia; Introduction; General Treatment Considerations; Who Should Be Treated?; First-Line Management; Corticosteroids; Mechanism of Action; Steroid Treatment Recommendations; Intravenous Immunoglobulin; Mechanism of Action; IVIG Treatment Recommendations.
  • Anti-D ImmunoglobulinMechanism of Action; Anti-D Treatment Recommendations; Second-Line Therapy; Splenectomy; Mechanism of Action; Splenectomy Treatment Recommendations; Rituximab; Mechanism of Action; Rituximab Treatment Recommendations; Thrombopoietin Receptor Agonists (TPO-RAs); Mechanism of Action; TPO-RA Adverse Effects; Treatment Recommendations; Use of TPO-RAs in Pediatric ITP; Use of TPO-RAs in Newly Diagnosed ITP; Management of Life-Threatening Bleeding; Other Agents; Antimetabolites; Novel Therapies; References; Part II: Autoimmune Hemolytic Anemia (AIHA).
  • Chapter 5: Background, Presentation and Pathophysiology of Autoimmune Hemolytic AnemiaHistory of Immune Hemolysis; Definitions and Classification; Warm AIHA; Pathophysiology; Clinical Features; Cold AIHA (Cold Agglutinin Disease); Pathophysiology; Clinical Features; Paroxysmal Cold Hemoglobinuria; Pathophysiology; Clinical Features; Mixed AIHA; References; Chapter 6: Treatment of Autoimmune Hemolytic Anemia; Introduction; Diagnosis and Classification; Etiology; Frontline Treatment; Blood Transfusions; Corticosteroids; Second-Line Treatments; Rituximab; Splenectomy; Immunosuppressive Therapies.

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