The value of BCG and TNF in autoimmunity /
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| Author / Creator: | Faustman, Denise, author. |
|---|---|
| Edition: | Second edition. |
| Imprint: | London, United Kingdom ; San Diego, CA, United States : Academic Press, [2018] |
| Description: | 1 online resource |
| Language: | English |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11678729 |
Table of Contents:
- Front Cover; The Value of BCG and TNF in Autoimmunity; Copyright; Dedication; Contents; Contributors; Introduction; Chapter 1 BCG: Its Impact on Tuberculosis and Relevance to Autoimmune Disease; Origins; Current BCG Vaccines; BCG and Protection Against TB; Mechanism of Protection; Nonspecific Effects of BCG; Some Intriguing Connections With Diabetes; References; Chapter 2 The Potential of TNF Induction From BCG for the Treatment of Type 1 Diabetes; Signaling Defects in the TNF Pathway Make Autoreactive T Cells Vulnerable to Apoptosis After TNF Elevations From BCG
- TNF Induction and TNFR2 Agonism Trigger Treg ExpansionTreating Type 1 Diabetes in the NOD Mouse With BCG or TNFR2 Agonism; The BCG Vaccine in Type 1 Diabetes: Strain Differences, Dose, and Timing for Maximal Efficacy?; Does BCG Work Through Other Pathways Than Transmembrane TNF and TNFR2 Receptor?; TNFR2 Agonism as a Treatment for Type 1 Diabetes; Conclusions; References; Chapter 3 Bacille Calmette-Guérin (BCG) Vaccine in Neuroinflammation; Bacille Calmette-Guerin (BCG) and Other Vaccines in Multiple Sclerosis (MS); Temporal Dynamics of BCG Vaccine Effects in MS
- BCG Vaccine in Clinically Isolated Syndromes (CIS)BCG Vaccine in Radiologically Isolated Syndromes (RIS); BCG Vaccine in Neuroinflammation and Neurodegenerative Diseases; References; Chapter 4 Host Epigenetic Modifications in Mycobacterium tuberculosis Infection: A Boon or Bane; Introduction; Epigenetic Modifications: A Mechanistic Approach; DNA Methylation; Histone Modifications; Noncoding RNAs; Epigenetic Modifications: A Tool Employed by M. tuberculosis to Promote Its Survival; Role of Chromatin Modifications in M.tb Infection and Immune Evasion; Role of RNA Interference in TB Infection
- Role of DNA Methylation in TB Infection and Its Survival Inside a HostFuture Prospects; References; Further Reading; Chapter 5 Mycobacterium Bovis Bacille Calmette-Guerin Vaccination: Can Biomarkers Predict Efficacy?; Introduction; Biomarkers That Predict Protection; Back to Basics and Growth Inhibition of BCG; What Influences the Biomarkers Induced by BCG Vaccination in Different Settings?; Does Variability in Immune Responses and Measured Biomarkers Matter?; Conclusions; Acknowledgments; References
- Chapter 6 The Heterologous Effects of Bacillus Calmette-Guérin (BCG) Vaccine and Trained Innate ImmunityThe BCG Vaccine; Nonspecific (Heterologous) Effects of BCG Vaccine; Human Epidemiological Studies; BCG and Infectious Diseases; BCG and Cancer; BCG and Allergy; BCG and Immunomodulation; Cytokine Studies; Vaccine Response Studies; Immunological Mechanisms; Adaptive Immune Cells; Innate Immune Cells; Trained Innate Immunity; Immunometabolic Reprogramming in Trained Immunity; Epigenetic/Chromatin Reprogramming in Trained Immunity; Evidence for BCG-Induced TRAINED IMMUNITY; In Vivo Experiments