Prebiotic chemistry and chemical evolution of nucleic acids /
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| Imprint: | Cham, Switzerland : Springer, 2018. |
|---|---|
| Description: | 1 online resource (xvi, 291 pages) : illustrations (some color) |
| Language: | English |
| Series: | Nucleic acids and molecular biology, 0933-1891 ; volume 35 Nucleic acids and molecular biology ; v. 35. |
| Subject: | |
| Format: | E-Resource Book |
| URL for this record: | http://pi.lib.uchicago.edu/1001/cat/bib/11690156 |
Table of Contents:
- Intro; Preface; Outline; Stanley L. Miller: A Personal Retrospective; References; Contents; Chapter 1: Nucleobases on the Primitive Earth: Their Sources and Stabilities; 1.1 Introduction; 1.1.1 Nomenclature, Structure, and Physical Chemistry; 1.1.2 The Relevance of Nucleobase to the Origins of Life; 1.2 Prebiotic Synthesis of Nucleobases; 1.2.1 General Background; 1.2.2 Retrosynthetic Analysis; 1.2.3 Purine Nucleobase Synthesis from One-Carbon Compounds; 1.2.3.1 Synthesis from HCN and Formamide; 1.2.3.2 One-Pot Purine Synthesis in Electric Discharges and Eutectics; 1.2.4 Pyrimidine Synthesis
- 1.2.4.1 Pyrimidine Synthesis from C3 Precursors1.2.4.2 Pyrimidine Synthesis from C1 Precursors; 1.3 Extraterrestrial Nucleobases; 1.4 The Stability of the Nucleobases; 1.4.1 Thermal Decomposition; 1.4.2 Decomposition by Ionizing Radiation; 1.5 Conclusions and Future Directions; References; Chapter 2: Condensation and Decomposition of Nucleotides in Simulated Hydrothermal Fields; 2.1 Introduction; 2.1.1 A Laboratory Simulation of HD Cycles; 2.2 Results and Discussion; 2.2.1 Stability of RNA Under Simulation Conditions; 2.2.2 Condensation Reactions
- 2.2.3 Gel Electrophoresis of Condensation Products2.2.4 Effect of Temperature, pH, and Ionic Solutes on Depurination; 2.2.5 Hydrolysis and Depurination Are Sufficiently Slow for Polymers to Accumulate; References; Chapter 3: Mineral-Organic Interactions in Prebiotic Synthesis; 3.1 Introduction; 3.1.1 Decisions Must Be Made; 3.1.2 The Logic Of Plausibility; 3.1.3 The Correspondence Principle; 3.1.4 The ``RNA First Hypothesis;́́ 3.1.5 What Makes a Model Persuasive; 3.2 The Planetary History; 3.2.1 Choices Made Concerning Planetary History
- 3.2.1.1 Deciding What Cosmogenic Factors to Build into the ModelInitial Accretion; Formation of the Moon; The ``Late Veneer ́́(LV); The Late Heavy Bombardment (LHB); 3.2.2 The Geological Consequence of the Model Derived from These Choices; 3.2.3 What Organic Species Are Available from the Atmosphere?; 3.2.4 Local Variation in Mineral Species Available from the Mantle and Crust; 3.2.5 When Is a Mineral Considered Impossible; 3.3 Classical Literature on Minerals; 3.3.1 Classical Prebiotic Chemistry Involving Minerals: Clays
- 3.3.2 Classical Prebiotic Chemistry Involving Minerals: Pyrites and Other Sulfides3.3.3 Classical Prebiotic Chemistry Involving Minerals: Silicates, Oxides, and Others; 3.4 How to Tackle the RNA First Problem Using Mineralogy; 3.4.1 Paradoxes; 3.4.1.1 The Tar Paradox; 3.4.1.2 The Phosphate Paradox; 3.4.1.3 The Water Paradox; 3.4.1.4 The Chirality Problem; 3.4.1.5 The Information-Need Paradox; 3.4.1.6 The Biopolymer Stability Problem; 3.4.2 Minerals as a Source of Prebiotic Components; 3.4.2.1 Solutions to the Phosphate Problem: Acidification